(Q38560502)

4 September 2017

1 reference

title

Redox distress and genetic defects conspire in systemic autoinflammatory diseases (English)

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4 September 2017

1

Georg Varga

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Dirk Foell

series ordinal

3

object named as

Dirk Foell

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4 September 2017

Georg Varga

1

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4 September 2017

Marco Gattorno

series ordinal

2

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4 September 2017

Anna Rubartelli

series ordinal

4

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4 September 2017

language of work or name

English

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publication date

4 August 2015

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Nature Reviews Rheumatology

4 September 2017

published in

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4 September 2017

volume

11

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4 September 2017

issue

11

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4 September 2017

page(s)

670-680

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2015.105

4 September 2017

exact match

0 references

cites work

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Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation with MEFV genotype

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Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

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Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

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Interleukin-1 receptor antagonist: role in biology

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The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1.

31 March 2020

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Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells

31 March 2020

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Immune suppression via glucocorticoid-stimulated monocytes: a novel mechanism to cope with inflammation.

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Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition

31 March 2020

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Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations

31 March 2020

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Use of canakinumab in the cryopyrin-associated periodic syndrome

31 March 2020

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Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies

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An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

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Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in cryopyrin-associated periodic syndrome monocytes

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

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IL-1 family nomenclature

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Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis

31 March 2020

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Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

31 March 2020

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Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

31 March 2020

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Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

31 March 2020

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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

31 March 2020

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Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells

31 March 2020

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S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

31 March 2020

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Active caspase-1 is a regulator of unconventional protein secretion

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Tolerance, danger, and the extended family

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Ménage à Trois in stress: DAMPs, redox and autophagy

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

HMG-1 as a late mediator of endotoxin lethality in mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

High mobility group box 1 protein interacts with multiple Toll-like receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Characterization of the Inflammatory Properties of Actively Released HMGB1 in Juvenile Idiopathic Arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Ca2+ signaling and intracellular Ca2+ binding proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Neutrophil-derived S100A12 as novel biomarker of inflammation in familial Mediterranean fever

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Unconventional secretion: a stress on GRASP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

ATP release and purinergic signaling in NLRP3 inflammasome activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

ATP release from non-excitable cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

TLR costimulation causes oxidative stress with unbalance of proinflammatory and anti-inflammatory cytokine production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

CD39 and CD73 in immunity and inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Stress as an intercellular signal: the emergence of stress-associated molecular patterns (SAMP).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Pathogen-induced interleukin-1beta processing and secretion is regulated by a biphasic redox response.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

NF-kappaB activation by reactive oxygen species: fifteen years later

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Signaling by ROS drives inflammasome activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

A role for mitochondria in NLRP3 inflammasome activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Reactive oxygen species at the crossroads of inflammasome and inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Regulation of translation by hydrogen peroxide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Type I interferonopathies: mendelian type I interferon up-regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Activated STING in a vascular and pulmonary syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Extracellular ATP drives systemic inflammation, tissue damage and mortality.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Purinergic receptor P2X₇: a novel target for anti-inflammatory therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Potential impact of genetic variants in Nrf2 regulated antioxidant genes and risk prediction of diabetes and associated cardiac complications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Disease tolerance as a defense strategy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

The rate of interleukin-1beta secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Emerging functions of the unfolded protein response in immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Paneth cells as a site of origin for intestinal inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

31 March 2020

The UPR and lung disease

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Interplay between redox status and inflammasome activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Redox regulation of inflammation: old elements, a new story

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

HMGB1 is a therapeutic target for sterile inflammation and infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

Mechanisms of disease: a 'DAMP' view of inflammatory arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

The P2X7 receptor: a key player in IL-1 processing and release

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.105

A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26241183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRRHEUM.2015.105

1 reference

Dimensions Publication ID

4 September 2017

1053486456

0 references

1 reference