(Q38568948)

4 September 2017

title

The structural biology of biosynthetic megaenzymes (English)

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4 September 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284673%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Kira J Weissman

series ordinal

1

1 reference

4 September 2017

publication date

1 August 2015

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4 September 2017

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284673%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284673%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284673%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

660-670

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284673%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nchembio.1883

1 June 2020

exact match

0 references

cites work

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Modular organization of genes required for complex polyketide biosynthesis

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Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

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Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines

21 January 2018

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Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

21 January 2018

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Biosynthesis of polyketides by trans-AT polyketide synthases

21 January 2018

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Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

21 January 2018

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Ways of assembling complex natural products on modular nonribosomal peptide synthetases

21 January 2018

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Fatty acid synthase, a proficient multifunctional enzyme

21 January 2018

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Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA.

21 January 2018

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

21 January 2018

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Evidence for a double-helical structure for modular polyketide synthases.

21 January 2018

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Peptidyl transfers in gramicidin S bisoynthesis from enzyme-bound thioester intermediates

21 January 2018

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Evidence for a monomeric structure of nonribosomal Peptide synthetases

21 January 2018

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Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: mutant domain activity regain and ultracentrifugation studies

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

21 January 2018

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Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

21 January 2018

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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

21 January 2018

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Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

21 January 2018

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Structural basis for macrolactonization by the pikromycin thioesterase

21 January 2018

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Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels.

21 January 2018

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Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase

21 January 2018

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The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

21 January 2018

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Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

A tylosin ketoreductase reveals how chirality is determined in polyketides

21 January 2018

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Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase

21 January 2018

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Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases

21 January 2018

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Divergence of multimodular polyketide synthases revealed by a didomain structure

21 January 2018

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Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

21 January 2018

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Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The structure of docking domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural analysis of protein-protein interactions in type I polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural and functional organization of the animal fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Active-site residue, domain and module swaps in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

A Double-Hotdog with a New Trick: Structure and Mechanism of the trans -Acyltransferase Polyketide Synthase Enoyl-isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Crystal structure of Bacillus cereus D-alanyl carrier protein ligase (DltA) in complex with ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structure of the epimerization domain of tyrocidine synthetase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structure of the adenylation-peptidyl carrier protein didomain of the Microcystis aeruginosa microcystin synthetase McyG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Crystal structure of the termination module of a nonribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Nonribosomal peptide synthetases: structures and dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Architecture of the polyketide synthase module: surprises from electron cryo-microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The crystal structure of a mammalian fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structure of a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Structural rearrangements of a polyketide synthase module during its catalytic cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Uncovering the structures of modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes

21 January 2018

1 reference

12 December 2020

Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity

1 reference

12 December 2020

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

1 reference

12 December 2020

Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates

1 reference

12 December 2020

Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described

1 reference

12 December 2020

Modular polyketide synthases (PKSs): a new model fits all?

1 reference

12 December 2020

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

1 reference

12 December 2020

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

1 reference

12 December 2020

The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide

1 reference

12 December 2020

Multienzymatic non ribosomal peptide biosynthesis: identification of the functional domains catalysing peptide elongation and epimerisation

1 reference

12 December 2020

On the domain construction of the multienzyme gramicidin S synthetase 2. Isolation of domains activating valine and leucine

1 reference

12 December 2020

The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1883

7 January 2021