(Q38259700)

1 September 2017

1 reference

title

Uncovering the structures of modular polyketide synthases (English)

1 reference

1 September 2017

Kira J Weissman

1

1 reference

1 September 2017

publication date

1 March 2015

1 reference

1 September 2017

published in

Natural Product Reports

1 reference

1 September 2017

volume

32

1 reference

1 September 2017

issue

3

1 reference

1 September 2017

page(s)

436-453

1 reference

Natural products and Pharma 2011: strategic changes spur new opportunities

1 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The biosynthetic logic of polyketide diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Biosynthesis of polyketides by trans-AT polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

GNAT-like strategy for polyketide chain initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

An enzymatic domain for the formation of cyclic ethers in complex polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Isoprenoid-like alkylations in polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Evolutionary implications of bacterial polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Combinatorial biosynthesis of reduced polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structural analysis of protein-protein interactions in type I polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structure of a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structural rearrangements of a polyketide synthase module during its catalytic cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Evidence for a double-helical structure for modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The crystal structure of a mammalian fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Divergence of multimodular polyketide synthases revealed by a didomain structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Developments in x-ray crystallographic structure determination of biological macromolecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Cryo-electron microscopy--a primer for the non-microscopist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structural characterization of proteins and complexes using small-angle X-ray solution scattering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Small-angle scattering for structural biology--expanding the frontier while avoiding the pitfalls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The type I fatty acid and polyketide synthases: a tale of two megasynthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Conformational flexibility of metazoan fatty acid synthase enables catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The structures of type I polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The structure of docking domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

A new enzyme superfamily - the phosphopantetheinyl transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structural characterisation and functional significance of transient protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Transient protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

An antibiotic factory caught in action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Peptidyl thiophenols as substrates for nonribosomal peptide cyclases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

A tylosin ketoreductase reveals how chirality is determined in polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Protein-protein interactions in multienzyme megasynthetases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Solution structure of the tandem acyl carrier protein domains from a polyunsaturated fatty acid synthase reveals beads-on-a-string configuration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Linking folding and binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

The origins of specificity in polyketide synthase protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Multienzyme docking in hybrid megasynthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Crystal structure of the termination module of a nonribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

DKxanthene biosynthesis--understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4NP00098F

21 January 2018

Identifiers

DOI

10.1039/C4NP00098F

1 reference

release_urjd7mm5srcbnipmh6cpf53t6u

1 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/urjd7mm5srcbnipmh6cpf53t6u

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference