(Q38031740)

27 August 2017

title

The structures of type I polyketide synthases (English)

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27 August 2017

author name string

Adrian T Keatinge-Clay

series ordinal

1

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27 August 2017

publication date

3 August 2012

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27 August 2017

published in

Natural Product Reports

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27 August 2017

volume

29

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27 August 2017

issue

10

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27 August 2017

page(s)

1050-1073

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Revisiting the structures of several antibiotics bound to the bacterial ribosome

27 August 2017

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10-formyltetrahydrofolate dehydrogenase requires a 4'-phosphopantetheine prosthetic group for catalysis

21 January 2018

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Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula

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Tandem acyl carrier protein domains in polyunsaturated fatty acid synthases

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Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

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Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase

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21 January 2018

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A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains

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Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

21 January 2018

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Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.

21 January 2018

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Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases

21 January 2018

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Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase

21 January 2018

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Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase

21 January 2018

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Recognition and accommodation at the androgen receptor coactivator binding interface

21 January 2018

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Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains

21 January 2018

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The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component

21 January 2018

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Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design

21 January 2018

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Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole Synthase

21 January 2018

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Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography

21 January 2018

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Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase

21 January 2018

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Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases

21 January 2018

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ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

21 January 2018

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Recognition of (2S)-aminomalonyl-acyl carrier protein (ACP) and (2R)-hydroxymalonyl-ACP by acyltransferases in zwittermicin A biosynthesis

21 January 2018

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SBSPKS: structure based sequence analysis of polyketide synthases

21 January 2018

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Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.

21 January 2018

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Editing mechanisms in protein synthesis. Rejection of valine by the isoleucyl-tRNA synthetase

21 January 2018

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Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

21 January 2018

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Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria

21 January 2018

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Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes

21 January 2018

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

21 January 2018

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Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae

21 January 2018

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An antibiotic factory caught in action

21 January 2018

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Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine

21 January 2018

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Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase

21 January 2018

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The Biosynthesis of Long-Chain Fatty Acids. Stereochemical Differentiation in the Enzymic Incorporation of Chiral Acetates

21 January 2018

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Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases

21 January 2018

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Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation

21 January 2018

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Crystal structure of catechol O-methyltransferase

21 January 2018

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SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

21 January 2018

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Divergence of multimodular polyketide synthases revealed by a didomain structure

21 January 2018

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Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes

21 January 2018

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Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.

21 January 2018

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Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Crystal structure of yeast peroxisomal multifunctional enzyme: structural basis for substrate specificity of (3R)-hydroxyacyl-CoA dehydrogenase units

21 January 2018

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A tylosin ketoreductase reveals how chirality is determined in polyketides

21 January 2018

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Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase

21 January 2018

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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

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A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

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A fungal ketoreductase domain that displays substrate-dependent stereospecificity

21 January 2018

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Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase

21 January 2018

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Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

The biochemical basis for stereochemical control in polyketide biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

21 January 2018

1 reference

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Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

21 January 2018

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Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

21 January 2018

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Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site

21 January 2018

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The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa.

21 January 2018

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Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Crystal Structure ofEscherichia coliQOR Quinone Oxidoreductase Complexed with NADPH

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Experimental mapping of soluble protein domains using a hierarchical approach

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Evidence for a double-helical structure for modular polyketide synthases.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2NP20019H

Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Structural basis for macrolactonization by the pikromycin thioesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo- -linolenic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

A multiplasmid approach to preparing large libraries of polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

A labile point in mutant amphotericin polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

SCWRL and MolIDE: computer programs for side-chain conformation prediction and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Automated genome mining for natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

Clustal W and Clustal X version 2.0

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20019H

21 January 2018

Identifiers

DOI

10.1039/C2NP20019H

1 reference

27 August 2017

1 reference