(Q46788614)

25 December 2017

title

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection (English)

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25 December 2017

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4

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Christian Hertweck

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25 December 2017

Keishi Ishida

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object named as

Keishi Ishida

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25 December 2017

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Matthias Platzer

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25 December 2017

Stefan Taudien

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object named as

Stefan Taudien

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25 December 2017

author name string

TuAnh Nguyen

1

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25 December 2017

Holger Jenke-Kodama

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25 December 2017

Cristian Gurgui

5

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25 December 2017

Thomas Hochmuth

6

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Jörn Piel

10

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25 December 2017

publication date

27 January 2008

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25 December 2017

published in

Nature Biotechnology

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25 December 2017

volume

26

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page(s)

225-233

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issue

2

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25 December 2017

https://scigraph.springernature.com/pub.10.1038/nbt1379

exact match

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The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.

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Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56

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Macrolactin is the Polyketide Biosynthesis Product of the pks2 Cluster of Bacillus amyloliquefaciens FZB42

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Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases

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The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase

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A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus

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Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae

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Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia

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Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic.

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Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis

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Widespread occurrence and genomic context of unusually small polyketide synthase genes in microbial consortia associated with marine sponges

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MRBAYES: Bayesian inference of phylogenetic trees

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Type I polyketide synthases may have evolved through horizontal gene transfer

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Naturally mosaic operons for secondary metabolite biosynthesis: variability and putative horizontal transfer of discrete catalytic domains of the epothilone polyketide synthase locus

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The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli

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Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis

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Pathogenic fungus harbours endosymbiotic bacteria for toxin production

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Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase

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Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations.

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7 January 2021

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1038/NBT1379

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25 December 2017

PubMed ID

18223641

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25 December 2017