(Q46788614)

25 December 2017

title

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection (English)

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25 December 2017

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4

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Christian Hertweck

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25 December 2017

Keishi Ishida

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object named as

Keishi Ishida

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25 December 2017

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Matthias Platzer

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25 December 2017

Stefan Taudien

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object named as

Stefan Taudien

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25 December 2017

author name string

TuAnh Nguyen

1

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25 December 2017

Holger Jenke-Kodama

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25 December 2017

Cristian Gurgui

5

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25 December 2017

Thomas Hochmuth

6

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Jörn Piel

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25 December 2017

publication date

27 January 2008

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25 December 2017

published in

Nature Biotechnology

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25 December 2017

volume

26

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issue

2

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25 December 2017

page(s)

225-233

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25 December 2017

A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach

cites work

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

21 January 2018

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A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

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Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei

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The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.

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7 January 2021

Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42.

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7 January 2021

Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina

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7 January 2021

Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56

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7 January 2021

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

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7 January 2021

Macrolactin is the Polyketide Biosynthesis Product of the pks2 Cluster of Bacillus amyloliquefaciens FZB42

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7 January 2021

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

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7 January 2021

Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases

1 reference

7 January 2021

The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase

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7 January 2021

A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus

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7 January 2021

Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae

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7 January 2021

Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia

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7 January 2021

Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic.

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7 January 2021

Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis

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7 January 2021

Evolutionary implications of bacterial polyketide synthases

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7 January 2021

Widespread occurrence and genomic context of unusually small polyketide synthase genes in microbial consortia associated with marine sponges

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7 January 2021

MRBAYES: Bayesian inference of phylogenetic trees

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7 January 2021

Type I polyketide synthases may have evolved through horizontal gene transfer

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7 January 2021

Naturally mosaic operons for secondary metabolite biosynthesis: variability and putative horizontal transfer of discrete catalytic domains of the epothilone polyketide synthase locus

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7 January 2021

The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli

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7 January 2021

Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis

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7 January 2021

Sequence around the 159 degree region of the Bacillus subtilis genome: the pksX locus spans 33.6 kb.

1 reference

7 January 2021

Bacillaene, a Novel Inhibitor of Procaryotic Protein Synthesis Produced by Bacillus subtilis: Production, Taxonomy, Isolation, Physico-chemical Characterization and Biological Activity

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7 January 2021

The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

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7 January 2021

Pathogenic fungus harbours endosymbiotic bacteria for toxin production

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7 January 2021

Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase

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7 January 2021

Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes.

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7 January 2021

Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations.

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7 January 2021

Genetic Contributions to Understanding Polyketide Synthases

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7 January 2021

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

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7 January 2021

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

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7 January 2021

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

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7 January 2021

Biosynthesis of nonribosomal peptides1.

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7 January 2021

The biology of natural transformation

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7 January 2021

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

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7 January 2021

Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family

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7 January 2021

Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei

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7 January 2021

Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects

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7 January 2021

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

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7 January 2021

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

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7 January 2021

Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians

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7 January 2021

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

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7 January 2021

ProtTest: selection of best-fit models of protein evolution

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7 January 2021

Rapid isolation of rare clones from highly complex DNA libraries by PCR analysis of liquid gel pools.

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7 January 2021

Identifiers

DOI

10.1038/NBT1379

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25 December 2017

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25 December 2017