(Q38572102)

4 September 2017

Deoxyribonucleotide metabolism, mutagenesis and cancer (English)

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4 September 2017

Christopher K Mathews

series ordinal

1

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PubMed ID

26299592

4 September 2017

language of work or name

English

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publication date

1 August 2015

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4 September 2017

Nature Reviews Cancer

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4 September 2017

15

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4 September 2017

9

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4 September 2017

528-539

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https://scigraph.springernature.com/pub.10.1038/nrc3981

4 September 2017

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cites work

STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI

1 reference

THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES

21 January 2018

1 reference

International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability

21 January 2018

1 reference

The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

21 January 2018

1 reference

DNA precursor metabolism and genomic stability

21 January 2018

1 reference

Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation

21 January 2018

1 reference

Mitochondrial deoxynucleotide pools in quiescent fibroblasts: a possible model for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

21 January 2018

1 reference

The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters

21 January 2018

1 reference

Targeting mitochondria metabolism for cancer therapy

21 January 2018

1 reference

DNA precursor pools and ribonucleotide reductase activity: distribution between the nucleus and cytoplasm of mammalian cells

21 January 2018

1 reference

dNTP pools determine fork progression and origin usage under replication stress

21 January 2018

1 reference

Ribonucleotide reductases

21 January 2018

1 reference

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

21 January 2018

1 reference

In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase

21 January 2018

1 reference

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

21 January 2018

1 reference

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

21 January 2018

1 reference

Mouse ribonucleotide reductase control: influence of substrate binding upon interactions with allosteric effectors

21 January 2018

1 reference

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

21 January 2018

1 reference

Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitro

21 January 2018

1 reference

Nucleoside triphosphate pool asymmetry in mammalian mitochondria

21 January 2018

1 reference

Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis

21 January 2018

1 reference

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

21 January 2018

1 reference

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

21 January 2018

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Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.

21 January 2018

1 reference

Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA

21 January 2018

1 reference

Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus

21 January 2018

1 reference

Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis

21 January 2018

1 reference

Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency

21 January 2018

1 reference

Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.

21 January 2018

1 reference

S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region

21 January 2018

1 reference

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

21 January 2018

1 reference

Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.

21 January 2018

1 reference

Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

21 January 2018

1 reference

Cell cycle-dependent metabolism of pyrimidine deoxynucleoside triphosphates in CEM cells

21 January 2018

1 reference

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

21 January 2018

1 reference

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

21 January 2018

1 reference

Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

21 January 2018

1 reference

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

21 January 2018

1 reference

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

21 January 2018

1 reference

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

21 January 2018

1 reference

GTP is the primary activator of the anti-HIV restriction factor SAMHD1.

21 January 2018

1 reference

Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates

21 January 2018

1 reference

Structural basis of cellular dNTP regulation by SAMHD1.

21 January 2018

1 reference

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

21 January 2018

1 reference

Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1).

21 January 2018

1 reference

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

21 January 2018

1 reference

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

21 January 2018

1 reference

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

Human cancers express a mutator phenotype

21 January 2018

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Only three driver gene mutations are required for the development of lung and colorectal cancers

21 January 2018

1 reference

Volatility of Mutator Phenotypes at Single Cell Resolution

21 January 2018

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Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

21 January 2018

1 reference

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

21 January 2018

1 reference

Novel mutator mutants of E. coli nrdAB ribonucleotide reductase: insight into allosteric regulation and control of mutation rates

21 January 2018

1 reference

Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity

21 January 2018

1 reference

Dividing the workload at a eukaryotic replication fork

21 January 2018

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The eukaryotic replicative DNA polymerases take shape

21 January 2018

1 reference

Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae

21 January 2018

1 reference

Differential DNA mismatch repair underlies mutation rate variation across the human genome

21 January 2018

1 reference

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

21 January 2018

1 reference

Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli

21 January 2018

1 reference

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

21 January 2018

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Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli

21 January 2018

1 reference

Nucleotide deficiency promotes genomic instability in early stages of cancer development

21 January 2018

1 reference

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer

21 January 2018

1 reference

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

21 January 2018

1 reference

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

21 January 2018

1 reference

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

21 January 2018

1 reference

Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.

21 January 2018

1 reference

Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiency

21 January 2018

1 reference

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

21 January 2018

1 reference

Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms

21 January 2018

1 reference

A functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells

21 January 2018

1 reference

Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells

21 January 2018

1 reference

Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate

21 January 2018

1 reference

Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant

21 January 2018

1 reference

Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

21 January 2018

1 reference

The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro

21 January 2018

1 reference

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage

21 January 2018

1 reference

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

21 January 2018

1 reference

Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools

21 January 2018

1 reference

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

21 January 2018

1 reference

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance

21 January 2018

1 reference

Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication

21 January 2018

1 reference

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

21 January 2018

1 reference

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

21 January 2018

1 reference

Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence

21 January 2018

1 reference

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

21 January 2018

1 reference

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence

21 January 2018

1 reference

Nucleotide metabolism, oncogene-induced senescence and cancer

21 January 2018

1 reference

p53 mediates senescence-like arrest induced by chronic replicational stress

21 January 2018

1 reference

Senescence: a new weapon for cancer therapy

21 January 2018

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Initiation of genome instability and preneoplastic processes through loss of Fhit expression

21 January 2018

1 reference

Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase

21 January 2018

1 reference

Telomeric strategies: means to an end.

21 January 2018

1 reference

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

21 January 2018

1 reference

Telomerase and the aging process

21 January 2018

1 reference

Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture

21 January 2018

1 reference

Telomere length homeostasis responds to changes in intracellular dNTP pools

21 January 2018

1 reference

DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells

21 January 2018

1 reference

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

21 January 2018

1 reference

Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool

21 January 2018

1 reference

A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1

21 January 2018

1 reference

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

21 January 2018

1 reference

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

21 January 2018

1 reference

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

21 January 2018

1 reference

Assessing the metabolic function of the MutT 8-oxodeoxyguanosine triphosphatase in Escherichia coli by nucleotide pool analysis

21 January 2018

1 reference

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.

21 January 2018

1 reference

MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides

21 January 2018

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Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool

21 January 2018

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

21 January 2018

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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

21 January 2018

1 reference

The catalytic mechanism and structure of thymidylate synthase

21 January 2018

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Dynamics of uracil and 5-fluorouracil in DNA.

21 January 2018

1 reference

Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors

21 January 2018

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5-Fluorouracil: mechanisms of action and clinical strategies

21 January 2018

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Identification of genes conferring resistance to 5-fluorouracil

21 January 2018

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dGTP starvation in Escherichia coli provides new insights into the thymineless-death phenomenon

21 January 2018

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Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides

21 January 2018

1 reference

Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

21 January 2018

1 reference

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation

21 January 2018

1 reference

Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools

21 January 2018

1 reference

Internalization and Stability of a Thymidylate Synthase Peptide Inhibitor in Ovarian Cancer Cells

21 January 2018

1 reference

Cleavage of DNA by human NM23-H2/nucleoside diphosphate kinase involves formation of a covalent protein-DNA complex

21 January 2018

1 reference

SAMHD1: a new gene for CLL

31 March 2020

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Molecular genetics of colorectal cancer

31 March 2020

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Effect of dGTP concentration on human and CHO telomerase

31 March 2020

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X-ray diagnosis of pulmonary lesions

31 March 2020

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Inhibition of dihydrofolic reductase by aminopterin and amethopterin

31 March 2020

1 reference

Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture

31 March 2020

1 reference

12 December 2020

Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase

1 reference

12 December 2020

Chemotherapy and comparative biochemistry: G. H. A. Clowes memorial lecture

1 reference

12 December 2020

Ribonucleotide reductases

1 reference

12 December 2020

Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells

1 reference

12 December 2020

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

1 reference

12 December 2020

Formation of deoxycytidine phosphates from cytidine phosphates in extracts from Escherichia coli

1 reference

12 December 2020

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole

1 reference

12 December 2020

5-Fluorouracil substitution alters pre-mRNA splicing in vitro

1 reference

12 December 2020

Errors in DNA replication as a basis of malignant changes

1 reference

12 December 2020

Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3981

1 reference

PubMed ID

26299592

Dimensions Publication ID

4 September 2017

0 references

1 reference

PubMed ID

26299592