(Q38592681)

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Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors

scientific article published on December 2015

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Europe PubMed Central

4 September 2017

Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors (English)

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Europe PubMed Central

4 September 2017

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neoplastic stem cells

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Gregg L Semenza

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Europe PubMed Central

PubMed ID

26405042

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4 September 2017

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English

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1 December 2015

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stated in

Europe PubMed Central

4 September 2017

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Europe PubMed Central

4 September 2017

129

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Europe PubMed Central

4 September 2017

12

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stated in

Europe PubMed Central

4 September 2017

1037-1045

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stated in

Europe PubMed Central

4 September 2017

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

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HIF induces human embryonic stem cell markers in cancer cells.

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Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

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TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

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Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 October 2022

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Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF

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The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

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Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

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Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

1 reference

12 October 2022

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Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.

1 reference

12 October 2022

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Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.

1 reference

12 October 2022

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CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

1 reference

12 October 2022

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The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia

1 reference

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An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

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Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

1 reference

12 October 2022

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Mammary Stem Cells. Preface.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Metastatic stem cells: sources, niches, and vital pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Loss of fibroblast HIF-1α accelerates tumorigenesis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors

1 reference

12 October 2022

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Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

1 reference

12 October 2022

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FDA pulls approval for avastin in breast cancer

1 reference

12 October 2022

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Collagen prolyl hydroxylases are essential for breast cancer metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

1 reference

12 October 2022

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Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Prospective identification of tumorigenic breast cancer cells

1 reference

12 October 2022

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Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

1 reference

12 October 2022

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

1 reference

12 October 2022

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HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

1 reference

12 October 2022

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IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

1 reference

12 October 2022

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Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.

1 reference

12 October 2022

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Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

1 reference

12 October 2022

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Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

1 reference

12 October 2022

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Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia inducible factor-1alpha is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

The CD44+/CD24- phenotype is enriched in basal-like breast tumors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

The hippo signaling pathway in development and cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Tumor hypoxia and malignant progression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor–dependent breastcancer–mesenchymal stem cell bidirectional signaling promotesmetastasis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Emerging roles of TEAD transcription factors and its coactivators in cancers

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

VEGF as a therapeutic target in cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

HIF-1 and tumour radiosensitivity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Detection and characterization of tumor hypoxia using pO2 histography

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Purification and characterization of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1042/CS20150451

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DOI

10.1042/CS20150451

1 reference

stated in

Europe PubMed Central

4 September 2017

1 reference

Europe PubMed Central

PubMed ID

26405042

retrieved

4 September 2017

(Q38592681)

Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors

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