(Q38603051)

4 September 2017

title

The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways (English)

1 reference

4 September 2017

main subject

adverse outcome pathway

0 references

1 reference

Claire L Mellor

1

1 reference

4 September 2017

Fabian P Steinmetz

series ordinal

2

1 reference

4 September 2017

Mark T D Cronin

series ordinal

3

1 reference

4 September 2017

language of work or name

English

0 references

publication date

9 October 2015

1 reference

Critical Reviews in Toxicology

4 September 2017

published in

1 reference

4 September 2017

volume

46

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4 September 2017

issue

2

1 reference

4 September 2017

page(s)

138-152

1 reference

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

4 September 2017

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Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium

21 January 2018

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Malonyl-CoA: the regulator of fatty acid synthesis and oxidation

21 January 2018

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Molecular biology of the androgen receptor

21 January 2018

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Estrogen receptor alpha and beta subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells

21 January 2018

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Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

21 January 2018

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Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology.

21 January 2018

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What pharmacologists can learn from recent advances in estrogen signalling

21 January 2018

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Progestogen for preventing miscarriage

21 January 2018

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Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction.

21 January 2018

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21 January 2018

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21 January 2018

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Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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n-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice

21 January 2018

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21 January 2018

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

The use of intraocular corticosteroids

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

21 January 2018

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

21 January 2018

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Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor

21 January 2018

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21 January 2018

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Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis

21 January 2018

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21 January 2018

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Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessment

21 January 2018

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Targeting the pregnane X receptor in liver injury

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Identification of a nuclear receptor for bile acids

21 January 2018

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Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

1 reference

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Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet

21 January 2018

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Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

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Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

21 January 2018

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

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Adverse Health Effects in Humans Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)

21 January 2018

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The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).

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Modulation of RXR function through ligand design

21 January 2018

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Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?

21 January 2018

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Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Clinical practice. Combination estrogen-progestin oral contraceptives

21 January 2018

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Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Selective thyroid hormone receptor modulators

21 January 2018

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Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

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Role of glucocorticoids and the glucocorticoid receptor in metabolism: insights from genetic manipulations.

21 January 2018

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Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid

21 January 2018

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T channels and steroid biosynthesis: in search of a link with mitochondria

21 January 2018

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Regulation of androgen action

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Role of LXRs in control of lipogenesis

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation

21 January 2018

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Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Intravenous therapies for castration-resistant prostate cancer: toxicities and adverse events

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Pharmacological properties of mifepristone: toxicology and safety in animal and human studies

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Consequences of emergency contraceptives: the adverse effects

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Glucocorticoid receptor and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

The adverse outcome pathway concept: a pragmatic tool in toxicology.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

PXR and CAR in energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Morphological abnormalities in the brains of estrogen receptor beta knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

A role for estrogen receptor beta in the regulation of growth of the ventral prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Estradiol valerate/dienogest

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Agonist and antagonist binding to the nuclear vitamin D receptor: dynamics, mutation effects and functional implications

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

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Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Non-alcoholic fatty liver disease: an emerging pathological spectrum

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Sterol regulatory element-binding protein-1c is responsible for cholesterol regulation of ileal bile acid-binding protein gene in vivo. Possible involvement of liver-X-receptor.

21 January 2018

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Agranulocytosis with tonsillitis associated with methimazole therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

The kaleidoscope of glucorticoid effects on immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2015.1089471

10.3109/10408444.2015.1089471

21 January 2018

Identifiers

DOI

1 reference

4 September 2017

1 reference