(Q38606832)

4 September 2017

title

Glycosylation-directed quality control of protein folding (English)

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4 September 2017

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Chengchao Xu

1

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4 September 2017

Davis T W Ng

series ordinal

2

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4 September 2017

publication date

14 October 2015

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Nature Reviews Molecular Cell Biology

4 September 2017

published in

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4 September 2017

volume

16

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4 September 2017

issue

12

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4 September 2017

page(s)

742-752

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https://scigraph.springernature.com/pub.10.1038/nrm4073

4 September 2017

exact match

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Members of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves

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Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids

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Protein O-glycosylation in Saccharomyces cerevisiae: the protein O-mannosyltransferases Pmt1p and Pmt2p function as heterodimer

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Physical and functional association of human protein O-mannosyltransferases 1 and 2.

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Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

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O-mannosylation protects mutant alpha-factor precursor from endoplasmic reticulum-associated degradation

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Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

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Roles of O-mannosylation of aberrant proteins in reduction of the load for endoplasmic reticulum chaperones in yeast

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Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p

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O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae.

21 January 2018

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Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control

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Principles of cotranslational ubiquitination and quality control at the ribosome

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Quality control: ER-associated degradation: protein quality control and beyond

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Recent technical developments in the study of ER-associated degradation

21 January 2018

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Cleaning up in the endoplasmic reticulum: ubiquitin in charge

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The mammalian endoplasmic reticulum-associated degradation system

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Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

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A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

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The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron

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Addition of carbohydrate side chains at novel sites on influenza virus hemagglutinin can modulate the folding, transport, and activity of the molecule

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Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum

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Lectin control of protein folding and sorting in the secretory pathway

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Getting in and out from calnexin/calreticulin cycles

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Association of folding intermediates of glycoproteins with calnexin during protein maturation

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Regulation of MHC class I transport by the molecular chaperone, calnexin (p88, IP90).

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Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control

21 January 2018

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The Structure of calnexin, an ER chaperone involved in quality control of protein folding

21 January 2018

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Substrate-specific requirements for UGT1-dependent release from calnexin

21 January 2018

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Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme

21 January 2018

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Conformational requirements for glycoprotein reglucosylation in the endoplasmic reticulum

21 January 2018

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DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum

21 January 2018

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Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure

21 January 2018

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A complex of Pdi1p and the mannosidase Htm1p initiates clearance of unfolded glycoproteins from the endoplasmic reticulum

21 January 2018

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Protein sorting receptors in the early secretory pathway

21 January 2018

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Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast

21 January 2018

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Characterization of Schizosaccharomyces pombe ER alpha-mannosidase: a reevaluation of the role of the enzyme on ER-associated degradation

21 January 2018

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The MRH domain suggests a shared ancestry for the mannose 6-phosphate receptors and other N-glycan-recognising proteins

21 January 2018

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A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins

21 January 2018

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Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen

21 January 2018

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Yos9p detects and targets misfolded glycoproteins for ER-associated degradation

21 January 2018

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Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.

21 January 2018

1 reference

Defining the glycan destruction signal for endoplasmic reticulum-associated degradation

21 January 2018

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Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

21 January 2018

1 reference

Mnl1p, an alpha -mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins

21 January 2018

1 reference

Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system

21 January 2018

1 reference

Roles of protein-disulfide isomerase-mediated disulfide bond formation of yeast Mnl1p in endoplasmic reticulum-associated degradation

21 January 2018

1 reference

Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation

21 January 2018

1 reference

The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones

21 January 2018

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Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP.

21 January 2018

1 reference

Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant

21 January 2018

1 reference

Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity

21 January 2018

1 reference

Free oligosaccharides to monitor glycoprotein endoplasmic reticulum-associated degradation in Saccharomyces cerevisiae

21 January 2018

1 reference

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins.

21 January 2018

1 reference

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

21 January 2018

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OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

21 January 2018

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A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

21 January 2018

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Modularity of the Hrd1 ERAD complex underlies its diverse client range

21 January 2018

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The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.

21 January 2018

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Misfolded proteins induce aggregation of the lectin Yos9.

21 January 2018

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Usa1 functions as a scaffold of the HRD-ubiquitin ligase.

21 January 2018

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Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

21 January 2018

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Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

21 January 2018

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A membrane protein required for dislocation of misfolded proteins from the ER

21 January 2018

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Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins

21 January 2018

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Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

21 January 2018

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Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p

21 January 2018

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Sec61p is part of the endoplasmic reticulum-associated degradation machinery

21 January 2018

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ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7.

21 January 2018

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Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p

21 January 2018

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Role of Cue1p in ubiquitination and degradation at the ER surface

21 January 2018

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HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

21 January 2018

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

21 January 2018

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

21 January 2018

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AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation

21 January 2018

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Key steps in ERAD of luminal ER proteins reconstituted with purified components

21 January 2018

1 reference

PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase

21 January 2018

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A role for N-glycanase in the cytosolic turnover of glycoproteins

21 January 2018

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Yeast N-glycanase distinguishes between native and non-native glycoproteins

21 January 2018

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In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase

21 January 2018

1 reference

A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation

21 January 2018

1 reference

Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome

21 January 2018

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Proteasome subunit Rpn1 binds ubiquitin-like protein domains

21 January 2018

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Rad4 regulates protein turnover at a postubiquitylation step

21 January 2018

1 reference

Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation

21 January 2018

1 reference

Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis

21 January 2018

1 reference

Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation

21 January 2018

1 reference

Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP.

21 January 2018

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Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system

21 January 2018

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Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates

21 January 2018

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A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

21 January 2018

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Characterization of early EDEM1 protein maturation events and their functional implications

21 January 2018

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Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

21 January 2018

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EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

21 January 2018

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A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins

21 January 2018

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EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog

21 January 2018

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ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER

21 January 2018

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EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans

21 January 2018

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A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation

21 January 2018

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Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

21 January 2018

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EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming

21 January 2018

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EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

21 January 2018

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Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

21 January 2018

1 reference

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

21 January 2018

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Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP

21 January 2018

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Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant.

21 January 2018

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Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate

21 January 2018

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OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation.

21 January 2018

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Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates

21 January 2018

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Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

21 January 2018

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The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation

21 January 2018

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Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation

21 January 2018

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

21 January 2018

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Protein O-mannosyltransferases participate in ER protein quality control

21 January 2018

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Green fluorescent protein as a marker for gene expression

21 January 2018

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Superfolder GFP is fluorescent in oxidizing environments when targeted via the Sec translocon

21 January 2018

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Futile protein folding cycles in the ER are terminated by the unfolded protein O-mannosylation pathway.

21 January 2018

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A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

21 January 2018

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Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells

21 January 2018

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O‐Glycosylation in Saccharomyces cerevisiae is initiated at the endoplasmic reticulum

21 January 2018

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Structure-function analysis of the dolichyl phosphate-mannose: protein O-mannosyltransferase ScPmt1p

31 March 2020

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Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

31 March 2020

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A major proportion of N-glycoproteins are transiently glucosylated in the endoplasmic reticulum

31 March 2020

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N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast

31 March 2020

1 reference

Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD

31 March 2020

1 reference

Vesicular stomatitis virus G proteins with altered glycosylation sites display temperature-sensitive intracellular transport and are subject to aberrant intermolecular disulfide bonding

31 March 2020

1 reference

12 December 2020

Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas

1 reference

12 December 2020

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Isolation and characterization of the gene encoding a specific processing alpha-mannosidase

1 reference

12 December 2020

Localization of dolichyl phosphate- and pyrophosphate-dependent glycosyl transfer reactions in Saccharomyces cerevisiae

1 reference

12 December 2020

Oligosaccharide trimming Man9-mannosidase is a resident ER protein and exhibits a more restricted and local distribution than glucosidase II

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM4073

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Dimensions Publication ID

4 September 2017

1042355037

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