(Q38627193)

4 September 2017

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics (English)

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4 September 2017

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Abdel A Belaidi

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Ashley I. Bush

object named as

Ashley I Bush

series ordinal

2

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language of work or name

English

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publication date

6 November 2015

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Journal of Neurochemistry

4 September 2017

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4 September 2017

139 Suppl 1

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4 September 2017

179-197

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Hemochromatosis and iron-overload screening in a racially diverse population.

4 September 2017

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

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Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

21 January 2018

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Aggregation and neurotoxicity of alpha-synuclein and related peptides

21 January 2018

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H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.

21 January 2018

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Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

21 January 2018

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Iron absorption and metabolism.

21 January 2018

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Mammalian iron metabolism and its control by iron regulatory proteins

21 January 2018

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Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

21 January 2018

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Ferritins: a family of molecules for iron storage, antioxidation and more.

21 January 2018

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Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

21 January 2018

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Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease

21 January 2018

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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

21 January 2018

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Biometals and their therapeutic implications in Alzheimer's disease.

21 January 2018

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Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.

21 January 2018

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Neurodegenerative diseases and oxidative stress

21 January 2018

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In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI.

21 January 2018

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Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

21 January 2018

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Brain iron uptake in hypotransferrinemic mice: influence of systemic iron status.

21 January 2018

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Role of iron in neurodegenerative disorders

21 January 2018

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Vulnerability of the nigrostriatal system as detected by transcranial ultrasound.

21 January 2018

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Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms.

21 January 2018

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Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis.

21 January 2018

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MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

21 January 2018

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Selective iron chelation in Friedreich ataxia: biologic and clinical implications.

21 January 2018

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Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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The importance of non-transferrin bound iron in disorders of iron metabolism

21 January 2018

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Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy

21 January 2018

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Intracellular labile iron.

21 January 2018

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Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states

21 January 2018

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Non-transferrin bound iron: a key role in iron overload and iron toxicity

21 January 2018

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Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

21 January 2018

1 reference

The significance of haemochromatosis gene mutations in the general population: implications for screening

21 January 2018

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The metallobiology of Alzheimer's disease

21 January 2018

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Twenty years of metallo-neurobiology: where to now?

21 January 2018

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Labile iron in cells and body fluids: physiology, pathology, and pharmacology

21 January 2018

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Iron-regulatory proteins: molecular biology and pathophysiological implications

21 January 2018

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Roles of the amyloid precursor protein family in the peripheral nervous system

21 January 2018

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Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging

21 January 2018

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Association between the HFE mutations and unsuccessful ageing: a study in Alzheimer's disease patients from Northern Italy.

21 January 2018

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Hypoxic/ischemic insult alters ferritin expression and myelination in neonatal rat brains.

21 January 2018

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Iron accumulates in Huntington's disease neurons: protection by deferoxamine

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease.

21 January 2018

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Relationship of iron to oligodendrocytes and myelination

21 January 2018

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Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains

21 January 2018

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A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains.

21 January 2018

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Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease

21 January 2018

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Isoforms of ferritin have a specific cellular distribution in the brain.

21 January 2018

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A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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Intramuscular desferrioxamine in patients with Alzheimer's disease

21 January 2018

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Iron metabolism--new perspectives in view

21 January 2018

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The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

21 January 2018

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Iron and transferrin uptake by brain and cerebrospinal fluid in the rat

21 January 2018

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Hepcidin and ferroportin: the new players in iron metabolism

21 January 2018

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Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

21 January 2018

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Targeting chelatable iron as a therapeutic modality in Parkinson's disease

21 January 2018

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Increased nigral iron content in postmortem parkinsonian brain.

21 January 2018

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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

21 January 2018

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Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

21 January 2018

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Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease

21 January 2018

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The role of iron and reactive oxygen species in cell death

21 January 2018

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Ferroptosis: an iron-dependent form of nonapoptotic cell death

21 January 2018

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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

21 January 2018

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21 January 2018

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Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

21 January 2018

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Two-year follow-up of amyloid deposition in patients with Alzheimer's disease.

21 January 2018

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The roles of neuromelanin, binding of metal ions, and oxidative cytotoxicity in the pathogenesis of Parkinson's disease: a hypothesis

21 January 2018

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Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: changes in transferrin uptake, iron handling and ferritin mRNA.

21 January 2018

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Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease.

21 January 2018

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An anemia of Alzheimer's disease.

21 January 2018

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Ageing and Parkinson's disease: substantia nigra regional selectivity

21 January 2018

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Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model.

21 January 2018

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Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice

21 January 2018

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

21 January 2018

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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

21 January 2018

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R2* mapping for brain iron: associations with cognition in normal aging.

21 January 2018

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Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

21 January 2018

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Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

21 January 2018

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Metal dyshomeostasis and oxidative stress in Alzheimer's disease

21 January 2018

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Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy

21 January 2018

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Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease

21 January 2018

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Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort

21 January 2018

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Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients.

21 January 2018

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Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

21 January 2018

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Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice

21 January 2018

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Imaging iron stores in the brain using magnetic resonance imaging

21 January 2018

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A delicate balance: Iron metabolism and diseases of the brain.

21 January 2018

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Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

21 January 2018

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Is early-life iron exposure critical in neurodegeneration?

21 January 2018

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Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation

21 January 2018

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Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution

21 January 2018

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DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression

21 January 2018

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Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

21 January 2018

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Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

21 January 2018

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

21 January 2018

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Characterization and distribution of ferritin binding sites in the adult mouse brain.

21 January 2018

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Ferroptosis as a p53-mediated activity during tumour suppression

21 January 2018

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Metals, oxidative stress and neurodegenerative disorders

21 January 2018

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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The TIM gene family: emerging roles in immunity and disease

21 January 2018

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Childhood disorders of neurodegeneration with brain iron accumulation (NBIA).

21 January 2018

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Long-term improvement under deferiprone in a case of neurodegeneration with brain iron accumulation.

21 January 2018

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MRI for iron mapping in Alzheimer's disease

21 January 2018

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Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

21 January 2018

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Tau protein: relevance to Parkinson's disease

21 January 2018

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

21 January 2018

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Motor and cognitive deficits in aged tau knockout mice in two background strains.

21 January 2018

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Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

21 January 2018

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Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

21 January 2018

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Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

21 January 2018

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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

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Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism

21 January 2018

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The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease

21 January 2018

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Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights.

21 January 2018

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Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

21 January 2018

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Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux

21 January 2018

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sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

21 January 2018

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Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

21 January 2018

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Molecular pathophysiology of Parkinson's disease

21 January 2018

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Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1.

21 January 2018

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Iron trafficking inside the brain

21 January 2018

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Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

21 January 2018

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Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration

21 January 2018

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HFE gene variants affect iron in the brain

21 January 2018

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Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

21 January 2018

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Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models.

21 January 2018

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Dementia-free centenarians

21 January 2018

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Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?

21 January 2018

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MRI estimates of brain iron concentration in normal aging: comparison of field-dependent (FDRI) and phase (SWI) methods.

21 January 2018

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Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study

21 January 2018

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Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy.

21 January 2018

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Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease

21 January 2018

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Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

21 January 2018

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Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE

21 January 2018

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High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.

21 January 2018

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Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2' mapping.

21 January 2018

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Perinatal iron deficiency and neurocognitive development

21 January 2018

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Systemic and cellular consequences of macrophage control of iron metabolism

21 January 2018

1 reference

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

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Differential effects of age and history of hypertension on regional brain volumes and iron

21 January 2018

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Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

21 January 2018

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

21 January 2018

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

21 January 2018

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Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins.

21 January 2018

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Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

21 January 2018

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Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

21 January 2018

1 reference

The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease.

21 January 2018

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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

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Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

21 January 2018

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Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA).

21 January 2018

1 reference

The role of iron in beta amyloid toxicity

21 January 2018

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A potential pathogenetic role of iron in Alzheimer's disease.

21 January 2018

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Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

21 January 2018

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A novel model for brain iron uptake: introducing the concept of regulation

21 January 2018

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Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities

21 January 2018

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

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Brain structural alterations before mild cognitive impairment.

21 January 2018

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Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

21 January 2018

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Iron, the substantia nigra and related neurological disorders

21 January 2018

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Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

21 January 2018

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Tim-2 is the receptor for H-ferritin on oligodendrocytes

21 January 2018

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H-ferritin is the major source of iron for oligodendrocytes

21 January 2018

1 reference

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Regulation of cellular iron metabolism

21 January 2018

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The role of iron in brain ageing and neurodegenerative disorders.

21 January 2018

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Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

21 January 2018

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Iron homeostasis and the inflammatory response

21 January 2018

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Chemistry and antihypertensive effects of tempol and other nitroxides

21 January 2018

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The molecular biology of human iron metabolism

21 January 2018

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A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe(2+) under physiologically relevant conditions.

21 January 2018

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β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin

21 January 2018

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Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier

21 January 2018

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Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

21 January 2018

1 reference

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

21 January 2018

1 reference

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

21 January 2018

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Iron, brain ageing and neurodegenerative disorders

21 January 2018

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Cellular iron status influences the functional relationship between microglia and oligodendrocytes.

21 January 2018

1 reference

The physiological functions of iron regulatory proteins in iron homeostasis - an update

21 January 2018

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Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease.

21 January 2018

1 reference

Neuromelanin of the human substantia nigra: an update

21 January 2018

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An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

21 January 2018

1 reference

Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.13425

1 reference

4 September 2017

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PubMed ID

26545340