(Q38679992)

5 September 2017

1 reference

title

Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research (English)

1 reference

5 September 2017

main subject

adverse outcome pathway

0 references

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Antonio F Hernandez

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Pablo Menendez

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

Susanne Hougaard Bennekou

11 June 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

2

Andrea Terron

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

EFSA WG EPI1 and its other members

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

23 May 2017

1 reference

5 September 2017

published in

Archives of Toxicology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

91

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

2763-2780

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28536863%20AND%20SRC:MED&resulttype=core&format=json

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

11 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Bioflavonoids as poisons of human topoisomerase II alpha and II beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Etoposide induces chimeric Mll gene fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Congenital leukaemia after heavy abuse of permethrin during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Use of Genome Engineering to Create Patient Specific MLL Translocations in Primary Human Hematopoietic Stem and Progenitor Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL leukemia induction by genome editing of human CD34+ hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Adverse Outcome Pathways-Organizing Toxicological Information to Improve Decision Making

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

The role of MLL in hematopoiesis and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Definitive hematopoiesis requires the mixed-lineage leukemia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

The many faces of histone H3K79 methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Topoisomerase II and the etiology of chromosomal translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

In utero pesticide exposure and leukemia in Brazilian children < 2 years of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

In utero rearrangements in the trithorax-related oncogene in infant leukaemias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

When one mutation is all it takes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Acute Lymphoblastic Leukemia in Children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

In vitro cleavage of the MLL gene by topoisomerase II inhibitor (etoposide) in normal cord and peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Molecular biology of therapy-related leukaemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Molecular pathogenesis of secondary acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Oxidative metabolites of curcumin poison human type II topoisomerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Dose-response modeling of etoposide-induced DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Etoposide-initiated MLL rearrangements detected at high frequency in human primitive hematopoietic stem cells with in vitro and in vivo long-term repopulating potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Chlorpyrifos Induces MLL Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

DNA topoisomerase II, genotoxicity, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

The MLL recombinome of acute leukemias in 2013.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Molecular mechanisms of etoposide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

21 January 2018

RAS diseases in children

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Targeting DNA topoisomerase II in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Topoisomerase II and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Secondary mutations in t(4;11) leukemia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Establishment of MLL/AF4 transgenic mice with the phenotype of lymphoblastic leukemia or lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Genotoxic sensitivity of the developing hematopoietic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Dietary flavonoids induce MLL translocations in primary human CD34+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Prenatal exposure to flavonoids: implication for cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

The adverse outcome pathway concept: a pragmatic tool in toxicology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X

Subclonality and prenatal origin ofRASmutations inKMT2A (MLL)-rearranged infant acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-017-1986-X