(Q38705494)

5 September 2017

A simple litmus test for aldehyde oxidase metabolism of heteroarenes (English)

1 reference

5 September 2017

Fionn O'Hara

1

1 reference

5 September 2017

Aaron C Burns

2

1 reference

5 September 2017

Michael R Collins

3

1 reference

5 September 2017

Deepak Dalvie

4

1 reference

5 September 2017

Martha A Ornelas

5

1 reference

5 September 2017

Alfin D N Vaz

6

1 reference

5 September 2017

Yuta Fujiwara

7

1 reference

5 September 2017

Phil S Baran

8

1 reference

5 September 2017

language of work or name

English

0 references

publication date

5 February 2014

1 reference

Journal of Medicinal Chemistry

5 September 2017

1 reference

5 September 2017

57

1 reference

5 September 2017

4

1 reference

5 September 2017

1616-1620

1 reference

Aldehyde oxidase and its importance in novel drug discovery: present and future challenges

5 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Mitigating heterocycle metabolism in drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

The role of aldehyde oxidase in drug metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

A new reagent for direct difluoromethylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Probing the links between in vitro potency, ADMET and physicochemical parameters.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Drug-metabolizing ability of molybdenum hydroxylases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Studies on the mechanism of aldehyde oxidase and xanthine oxidase

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Oxidative metabolism of carbazeran in vitro by liver cytosol of baboon and man.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

Quantitative study of the structural requirements of phthalazine/quinazoline derivatives for interaction with human liver aldehyde oxidase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983350

On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism

31 August 2018

1 reference

12 December 2020

Designing better drugs: predicting cytochrome P450 metabolism

1 reference

12 December 2020

Use of density functional calculations to predict the regioselectivity of drugs and molecules metabolized by aldehyde oxidase

1 reference

12 December 2020

Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM4017976

1 reference

5 September 2017

1 reference

5 September 2017

PubMed publication ID

24472070

1 reference