(Q38705756)

English

Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70

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scholarly article

1 reference

Europe PubMed Central

5 September 2017

Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70 (English)

1 reference

Europe PubMed Central

5 September 2017

allosteric inhibitor

1 reference

based on heuristic

inferred from title

Gabriela Chiosis

12

object named as

Gabriela Chiosis

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author name string

Yanlong Kang

1

1 reference

Europe PubMed Central

5 September 2017

Tony Taldone

2

1 reference

Europe PubMed Central

5 September 2017

Hardik J Patel

3

1 reference

Europe PubMed Central

5 September 2017

Pallav D Patel

4

1 reference

Europe PubMed Central

5 September 2017

Anna Rodina

5

1 reference

Europe PubMed Central

5 September 2017

Alexander Gozman

6

1 reference

Europe PubMed Central

5 September 2017

Ronnie Maharaj

7

1 reference

Europe PubMed Central

5 September 2017

Cristina C Clement

8

1 reference

Europe PubMed Central

5 September 2017

Maulik R Patel

9

1 reference

Europe PubMed Central

5 September 2017

Jeffrey L Brodsky

10

1 reference

Europe PubMed Central

5 September 2017

Jason C Young

11

1 reference

Europe PubMed Central

5 September 2017

language of work or name

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publication date

18 February 2014

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Europe PubMed Central

5 September 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

5 September 2017

57

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Europe PubMed Central

5 September 2017

1188-1207

1 reference

Europe PubMed Central

5 September 2017

4

1 reference

Europe PubMed Central

5 September 2017

Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap? A review of the clinical evidence

1 reference

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6 September 2017

A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

1 reference

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6 September 2017

The role of irreversible HER family inhibition in the treatment of patients with non-small cell lung cancer

1 reference

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6 September 2017

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

The resurgence of covalent drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Heat shock protein 70 (hsp70) as an emerging drug target.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Pharmacological targeting of the Hsp70 chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Allostery in Hsp70 chaperones is transduced by subdomain rotations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Heat shock proteins: essential proteins for apoptosis regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

A quantitative analysis of kinase inhibitor selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Crystal structure of the C-terminal three-helix bundle subdomain of C. elegans Hsp70

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Hsp70 chaperones: cellular functions and molecular mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

A small molecule-kinase interaction map for clinical kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Pathways of chaperone-mediated protein folding in the cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

The solution structure of the bacterial HSP70 chaperone protein domain DnaK(393–507) in complex with the peptide NRLLLTG

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

6 September 2017

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

A small molecule inhibitor of inducible heat shock protein 70.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

An apoptosis-inducing small molecule that binds to heat shock protein 70.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

14 September 2017

Synthesis and evaluation of novel rhodacyanine dyes that exhibit antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

25 September 2017

Concomitant determination of absolute values of cellular protein amounts, synthesis rates, and turnover rates by quantitative proteome profiling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

23 June 2018

Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

31 August 2018

ATPases as drug targets: insights from heat shock proteins 70 and 90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

31 August 2018

Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

31 August 2018

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983365

31 August 2018

Afatinib treatment in advanced non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24548207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Ethylmaleimide inactivates a nucleotide-free Hsp70 molecular chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/24548207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity of novel rhodacyanine dyes as antitumor agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/24548207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM401551N

1 reference

Europe PubMed Central

5 September 2017

1 reference

Europe PubMed Central

5 September 2017

1 reference

Europe PubMed Central

5 September 2017

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