(Q38770939)

6 September 2017

title

The role of leptin in diabetes: metabolic effects (English)

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6 September 2017

Thomas H Meek

1

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6 September 2017

Gregory J Morton

series ordinal

2

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6 September 2017

publication date

11 March 2016

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6 September 2017

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6 September 2017

volume

59

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6 September 2017

issue

5

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6 September 2017

page(s)

928-932

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https://scigraph.springernature.com/pub.10.1007/s00125-016-3898-3

6 September 2017

exact match

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cites work

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Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

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Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

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Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.

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Making insulin-deficient type 1 diabetic rodents thrive without insulin

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Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

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Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia

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Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats

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Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

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Role of leptin in the neuroendocrine response to fasting

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Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

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Metabolic manifestations of insulin deficiency do not occur without glucagon action

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Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

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Leptin deficiency causes insulin resistance induced by uncontrolled diabetes

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Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

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Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia.

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Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia

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Epinephrine supports the postabsorptive plasma glucose concentration and prevents hypoglycemia when glucagon secretion is deficient in man

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Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

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Role of central neural mechanisms in the regulation of hepatic glucose metabolism

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Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia

21 January 2018

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A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin

21 January 2018

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Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes

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Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin

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Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance

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A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia

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Genetic identification of a neural circuit that suppresses appetite

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AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

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Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats

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12 December 2020

Glucagon: Role in the Hyperglycemia of Diabetes Mellitus

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Leptin and diabetes in lipoatrophic mice

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12 December 2020

10.1007/S00125-016-3898-3

Identifiers

DOI

1 reference

Dimensions Publication ID

6 September 2017

1038415516

0 references

1 reference