(Q38790377)

6 September 2017

1 reference

title

Intramembrane proteases as drug targets (English)

1 reference

6 September 2017

Steven H L Verhelst

1

1 reference

PubMed ID

27889944

6 September 2017

language of work or name

English

0 references

publication date

27 November 2016

1 reference

6 September 2017

1 reference

6 September 2017

284

1 reference

6 September 2017

10

1 reference

6 September 2017

1489-1502

1 reference

Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in Man

6 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Emerging principles in protease-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Targeting proteases: successes, failures and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Function of site-2 proteases in bacteria and bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The mitochondrial rhomboid protease: its rise from obscurity to the pinnacle of disease-relevant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Biology of rhomboid proteases in infectious diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

An atomic structure of human γ-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Defining molecular targets to prevent Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Notch signalling in solid tumours: a little bit of everything but not all the time

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

A phase 3 trial of semagacestat for treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Small molecules that inhibit Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Notch signaling: an emerging therapeutic target for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Structure of a site-2 protease family intramembrane metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Small-molecule inhibitors of the Rce1p CaaX protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

BMS-708,163 targets presenilin and lacks notch-sparing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

γ-Secretase modulators: current status and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

γ-Secretase inhibitors and modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Development and mechanism of γ-secretase modulators for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Designed Helical Peptides Inhibit an Intramembrane Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Crystal structure of a rhomboid family intramembrane protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Structure of a presenilin family intramembrane aspartate protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The structural basis for catalysis and substrate specificity of a rhomboid protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

A miniaturized 1536-well format gamma-secretase assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Signature amyloid β profiles are produced by different γ-secretase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Novel γ-secretase enzyme modulators directly target presenilin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Drug discovery in the next decade: innovation needed ASAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The resurgence of covalent drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

A subset of membrane-altering agents and γ-secretase modulators provoke nonsubstrate cleavage by rhomboid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Clipping or Extracting: Two Ways to Membrane Protein Degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Focus on composition and interaction potential of single-pass transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

The roles of intramembrane proteases in protozoan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Intramembrane proteolysis in regulated protein trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Emerging roles for diverse intramembrane proteases in plant biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

Intramembrane proteolysis within lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13979

21 January 2018

Identifiers

DOI

10.1111/FEBS.13979

1 reference

6 September 2017

1 reference

PubMed ID

27889944