(Q38123209)

29 August 2017

title

Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012. (English)

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29 August 2017

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Martin Pettersson

1

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29 August 2017

Antonia F Stepan

series ordinal

2

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29 August 2017

Gregory W Kauffman

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3

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29 August 2017

Douglas S Johnson

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4

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29 August 2017

language of work or name

English

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publication date

23 July 2013

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Expert Opinion on Therapeutic Patents

29 August 2017

published in

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29 August 2017

volume

23

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29 August 2017

issue

10

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29 August 2017

page(s)

1349-1366

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Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

29 August 2017

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Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease

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Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

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BMS-708,163 targets presenilin and lacks notch-sparing activity

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The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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Novel γ-secretase modulators: a review of patents from 2008 to 2010.

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γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs

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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

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1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

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Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

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Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

21 January 2018

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Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs

21 January 2018

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Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

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Development and mechanism of γ-secretase modulators for Alzheimer's disease

21 January 2018

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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

21 January 2018

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Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment

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TASTPM Mice Expressing Amyloid Precursor Protein and Presenilin-1 Mutant Transgenes Are Sensitive to γ-Secretase Modulation and Amyloid-β<sub>42</sub> Lowering by GSM-10h

21 January 2018

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21 January 2018

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21 January 2018

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Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

21 January 2018

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Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease.

21 January 2018

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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator

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21 January 2018

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Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside

21 January 2018

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21 January 2018

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Escape from flatland: increasing saturation as an approach to improving clinical success.

21 January 2018

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Physiochemical drug properties associated with in vivo toxicological outcomes

21 January 2018

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Structure of a presenilin family intramembrane aspartate protease

21 January 2018

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γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin

21 January 2018

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10.1517/13543776.2013.821465

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

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