(Q39451354)

12 September 2017

title

Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment (English)

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12 September 2017

Ting Li

1

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12 September 2017

Yunhong Huang

2

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12 September 2017

Shiyi Jin

3

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12 September 2017

Liang Ye

4

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12 September 2017

Na Rong

5

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12 September 2017

Xiujuan Yang

6

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12 September 2017

Yu Ding

7

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12 September 2017

Ziqiang Cheng

8

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12 September 2017

Jinqiang Zhang

9

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12 September 2017

Zehong Wan

10

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12 September 2017

David C Harrison

11

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12 September 2017

Ishrut Hussain

12

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12 September 2017

Adrian Hall

13

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12 September 2017

Daniel Hong Seng Lee

14

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12 September 2017

Lit-Fui Lau

15

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12 September 2017

Yasuji Matsuoka

16

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12 September 2017

language of work or name

English

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publication date

13 March 2012

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Journal of Neurochemistry

12 September 2017

published in

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12 September 2017

volume

121

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12 September 2017

issue

2

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12 September 2017

page(s)

277-286

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A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

12 September 2017

cites work

1 reference

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The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression

21 January 2018

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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase

21 January 2018

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

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Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

21 January 2018

1 reference

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Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

21 January 2018

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Piperidine-derived gamma-secretase modulators

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Dynamics of Aβ42 reduction in plasma, CSF and brain of rats treated with the γ-secretase modulator, GSM-10h

21 January 2018

1 reference

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Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

21 January 2018

1 reference

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

The expression of presenilin 1 mRNA in skin fibroblasts and brains from sporadic Alzheimer's disease.

21 January 2018

1 reference

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Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Gamma-secretase modulation and its promise for Alzheimer's disease: a medicinal chemistry perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Gamma-secretase: substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Alzheimer's disease and the amyloid cascade hypothesis: ten years on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Direct regulation of intestinal fate by Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Among γ-secretase substrates Notch1 alone is sufficient to block neurogenesis but does not confer self-renewal properties to neural stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07560.X

10.1111/J.1471-4159.2011.07560.X

21 January 2018

Identifiers

DOI

1 reference

release_r4fmq33sgncgvkj43rre64j6x4

12 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/r4fmq33sgncgvkj43rre64j6x4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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