(Q40083147)

17 September 2017

title

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase (English)

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17 September 2017

11

Charles G Eberhart

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17 September 2017

Tong Li

1

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17 September 2017

Hongjin Wen

2

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17 September 2017

Cory Brayton

3

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17 September 2017

Pritam Das

4

1 reference

17 September 2017

Lisa A Smithson

5

1 reference

17 September 2017

Abdul Fauq

6

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17 September 2017

Xing Fan

7

1 reference

17 September 2017

Barbara J Crain

8

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17 September 2017

Donald L Price

9

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17 September 2017

Todd E Golde

10

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17 September 2017

Philip C Wong

12

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17 September 2017

language of work or name

English

0 references

publication date

7 September 2007

1 reference

Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

44

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17 September 2017

page(s)

32264-32273

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

17 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Intramembrane proteolysis: theme and variations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Notch1 functions as a tumor suppressor in mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Impaired notch signaling promotes de novo squamous cell carcinoma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Evaluating mutant mice: anatomic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

A common human skin tumour is caused by activating mutations in beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

beta-Catenin functions mainly as an adhesion molecule in patients with squamous cell cancer of the head and neck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Biological significance of c-erbB family oncogenes in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703649200

21 January 2018

Identifiers

DOI

10.1074/JBC.M703649200

1 reference

17 September 2017

1 reference