(Q38764862)

6 September 2017

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool (English)

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6 September 2017

20

Etienne Waelkens

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Cary Esselens

Cary Esselens

2

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Guillaume van Niel

Guillaume Van Niel

28

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Sebastian Munck

Sebastian Munck

18

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Joost Schymkowitz

Joost Schymkowitz

25

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Juan S. Bonifacino

Juan S Bonifacino

27

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Bart De Strooper

29

Bart De Strooper

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6 September 2017

19

Rita Derua

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6 September 2017

Ragna Sannerud

1

1 reference

6 September 2017

Paulina Ejsmont

3

1 reference

6 September 2017

Rafael Mattera

4

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6 September 2017

Leila Rochin

5

1 reference

6 September 2017

Arun Kumar Tharkeshwar

6

1 reference

6 September 2017

Greet De Baets

7

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6 September 2017

Veerle De Wever

8

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6 September 2017

Roger Habets

9

1 reference

6 September 2017

Veerle Baert

10

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6 September 2017

Wendy Vermeire

11

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6 September 2017

Christine Michiels

12

1 reference

6 September 2017

Arjan J Groot

13

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6 September 2017

Rosanne Wouters

14

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6 September 2017

Katleen Dillen

15

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6 September 2017

Katlijn Vints

16

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6 September 2017

Pieter Baatsen

17

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6 September 2017

Guriqbal S Basi

21

1 reference

6 September 2017

Mark Mercken

22

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6 September 2017

Marc Vooijs

23

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6 September 2017

Mathieu Bollen

24

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6 September 2017

Frederic Rousseau

26

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6 September 2017

Wim Annaert

30

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6 September 2017

language of work or name

English

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publication date

9 June 2016

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6 September 2017

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6 September 2017

166

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6 September 2017

1

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6 September 2017

193-208

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Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

6 September 2017

1 reference

12 December 2020

Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

1 reference

12 December 2020

RALA and RALBP1 regulate mitochondrial fission at mitosis

1 reference

12 December 2020

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

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12 December 2020

Increasing the precision of comparative models with YASARA NOVA-a self-parameterizing force field

1 reference

12 December 2020

Locus-specific mutation databases for neurodegenerative brain diseases

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12 December 2020

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

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12 December 2020

Signature amyloid β profiles are produced by different γ-secretase complexes

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12 December 2020

A fast growing spectrum of biological functions of γ-secretase in development and disease

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12 December 2020

Sorting of lysosomal proteins

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12 December 2020

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation

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12 December 2020

Rapid calcium-dependent activation of Aurora-A kinase.

1 reference

12 December 2020

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

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12 December 2020

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity

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12 December 2020

Aurora A kinase (AURKA) in normal and pathological cell division

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12 December 2020

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

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12 December 2020

Melanosomes--dark organelles enlighten endosomal membrane transport

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12 December 2020

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques

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12 December 2020

Reconstitution of gamma-secretase activity

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12 December 2020

Cargo recognition in clathrin-mediated endocytosis

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12 December 2020

The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

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12 December 2020

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

1 reference

12 December 2020

The FoldX web server: an online force field

1 reference

12 December 2020

Novel research horizons for presenilins and γ-secretases in cell biology and disease

1 reference

12 December 2020

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

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12 December 2020

Alzheimer's disease risk genes and mechanisms of disease pathogenesis

1 reference

12 December 2020

The rhomboid-like superfamily: molecular mechanisms and biological roles

1 reference

12 December 2020

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

1 reference

12 December 2020

Trafficking, a key player in regulated intramembrane proteolysis

1 reference

12 December 2020

Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons

1 reference

12 December 2020

Intramembrane-cleaving proteases

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12 December 2020

Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?

1 reference

12 December 2020

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

1 reference

12 December 2020

Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.

1 reference

12 December 2020

Familial Alzheimer's disease sustained by presenilin 2 mutations: systematic review of literature and genotype-phenotype correlation

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12 December 2020

Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?

1 reference

12 December 2020

Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

1 reference

12 December 2020

Alzheimer beta-amyloid peptides: normal and abnormal localization

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12 December 2020

Tumor vessel normalization by chloroquine independent of autophagy.

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12 December 2020

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

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12 December 2020

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

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12 December 2020

PMEL: a pigment cell-specific model for functional amyloid formation

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12 December 2020

Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants

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12 December 2020

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

1 reference

12 December 2020

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

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12 December 2020

Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation.

1 reference

12 December 2020

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

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12 December 2020

Gamma-secretase: proteasome of the membrane?

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12 December 2020

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins

1 reference

12 December 2020

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

12 December 2020

Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.

1 reference

12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

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12 December 2020

Adaptor proteins involved in polarized sorting

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12 December 2020

10.1016/J.CELL.2016.05.020

Identifiers

DOI

1 reference

6 September 2017

1 reference