(Q38794805)

6 September 2017

title

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9. (English)

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6 September 2017

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6

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12 June 2020

author name string

Ivailo Simoff

1

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12 June 2020

Maria Karlgren

2

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12 June 2020

Maria Backlund

3

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12 June 2020

Anne-Christine Lindström

4

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12 June 2020

Fabienne Z Gaugaz

5

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12 June 2020

Per Artursson

7

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12 June 2020

language of work or name

English

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publication date

1 February 2016

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Journal of Pharmaceutical Sciences

6 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869442%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

105

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12 June 2020

issue

2

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12 June 2020

page(s)

1017-1021

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869442%20AND%20SRC:MED&resulttype=core&format=json

Membrane transporters in drug development

12 June 2020

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

7 January 2021

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Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.

7 January 2021

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The MDCK variety pack: choosing the right strain

7 January 2021

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Kinetic analysis of human and canine P-glycoprotein-mediated drug transport in MDR1-MDCK cell model: approaches to reduce false-negative substrate classification.

7 January 2021

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Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?

7 January 2021

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Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

7 January 2021

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Influence of erythromycin on the pharmacokinetics of ximelagatran may involve inhibition of P-glycoprotein-mediated excretion.

7 January 2021

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Stable suppression of MDR1 gene expression and function by RNAi in Caco-2 cells

7 January 2021

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Development of a new permeability assay using low-efflux MDCKII cells.

7 January 2021

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Establishment of optimized MDCK cell lines for reliable efflux transport studies

7 January 2021

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Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases

7 January 2021

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Genome editing. The new frontier of genome engineering with CRISPR-Cas9

7 January 2021

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Development and applications of CRISPR-Cas9 for genome engineering

7 January 2021

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CRISPR-Cas systems for editing, regulating and targeting genomes

7 January 2021

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Cas9 as a versatile tool for engineering biology

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7 January 2021

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7 January 2021

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Quantitative targeted absolute proteomics for 28 human transporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and 4 weeks.

7 January 2021

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Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function

7 January 2021

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Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

7 January 2021

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Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): evasion of MRP-2 mediated efflux

7 January 2021

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7 January 2021

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Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport

7 January 2021

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10.1016/S0022-3549(15)00171-9

7 January 2021

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869442%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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