(Q38799137)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048809%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Necrosome core machinery: MLKL (English)

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31 March 2020

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4

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31 March 2020

author name string

Jing Zhang

series ordinal

1

1 reference

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31 March 2020

Yu Yang

series ordinal

2

1 reference

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31 March 2020

Wenyan He

series ordinal

3

1 reference

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31 March 2020

publication date

5 April 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048809%20AND%20SRC:MED&resulttype=core&format=json

Cellular and Molecular Life Sciences

31 March 2020

published in

1 reference

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31 March 2020

volume

73

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048809%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

issue

11-12

1 reference

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31 March 2020

page(s)

2153-2163

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https://scigraph.springernature.com/pub.10.1007/s00018-016-2190-5

31 March 2020

exact match

0 references

cites work

Caspase-independent cell killing by Fas-associated protein with death domain

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: early events in tumour necrosis factor-induced cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Necroptosis: The Trojan horse in cell autonomous antiviral host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Herpes simplex virus suppresses necroptosis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIPK1- and RIPK3-induced cell death mode is determined by target availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Structural insights into RIP3-mediated necroptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Activation of necroptosis in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Identification of RIP1 kinase as a specific cellular target of necrostatins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

RIP3 induces apoptosis independent of pronecrotic kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Membrane lipids: where they are and how they behave

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Channel-forming toxins: tales of transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Membrane insertion: The strategies of toxins (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Effects of MACPF/CDC proteins on lipid membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Perforin: structure, function, and role in human immunopathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

The structural basis for membrane binding and pore formation by lymphocyte perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Perforin and granzymes: function, dysfunction and human pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Lipid map of the mammalian cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2190-5

Complement System Part II: Role in Immunity

21 January 2018

1 reference

12 December 2020

Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

1 reference

12 December 2020

Complement System Part I - Molecular Mechanisms of Activation and Regulation

1 reference

12 December 2020

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.

1 reference

12 December 2020

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1 reference

12 December 2020

Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis

1 reference

12 December 2020

A plug release mechanism for membrane permeation by MLKL.

1 reference

12 December 2020

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

1 reference

12 December 2020

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

1 reference

12 December 2020

Necroptosis mediates TNF-induced toxicity of hippocampal neurons

1 reference

12 December 2020

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

1 reference

12 December 2020

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

1 reference

12 December 2020

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

1 reference

12 December 2020

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

1 reference

12 December 2020

10.1007/S00018-016-2190-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048809%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference