(Q38496608)

3 September 2017

1 reference

title

Perforin and granzymes: function, dysfunction and human pathology (English)

1 reference

3 September 2017

Joseph A Trapani

3

0 references

James C Whisstock

object named as

James C Whisstock

series ordinal

2

0 references

author name string

Ilia Voskoboinik

series ordinal

1

1 reference

PubMed ID

25998963

3 September 2017

language of work or name

1 reference

1 June 2015

1 reference

Nature Reviews Immunology

3 September 2017

1 reference

3 September 2017

15

1 reference

3 September 2017

6

1 reference

3 September 2017

388-400

1 reference

The role of the cytoskeleton at the immunological synapse

3 September 2017

1 reference

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.

31 March 2020

1 reference

Perforin deficiency and susceptibility to cancer

31 March 2020

1 reference

Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules

31 March 2020

1 reference

Familial and acquired hemophagocytic lymphohistiocytosis

31 March 2020

1 reference

Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. II. Morphogenesis of secretory granules and intracellular vacuoles

31 March 2020

1 reference

Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. I. Hypertrophy and change of orientation of the Golgi apparatus

31 March 2020

1 reference

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

31 March 2020

1 reference

Homology of perforin to the ninth component of complement (C9).

31 March 2020

1 reference

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

31 March 2020

1 reference

The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities

31 March 2020

1 reference

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

31 March 2020

1 reference

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes

31 March 2020

1 reference

A family of serine esterases in lytic granules of cytolytic T lymphocytes

31 March 2020

1 reference

Isolation and characterization of a serine esterase from cytolytic T cell granules

31 March 2020

1 reference

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

31 March 2020

1 reference

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

31 March 2020

1 reference

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

31 March 2020

1 reference

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

31 March 2020

1 reference

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

31 March 2020

1 reference

Human granzyme B is essential for DNA fragmentation of susceptible target cells

31 March 2020

1 reference

Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation

31 March 2020

1 reference

The isolation and sequence of a novel gene from a human functional T cell line

31 March 2020

1 reference

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

31 March 2020

1 reference

Apoptosis induced by the lymphocyte effector molecule perforin

31 March 2020

1 reference

Perforin-mediated target-cell death and immune homeostasis

31 March 2020

1 reference

The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells

31 March 2020

1 reference

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

31 March 2020

1 reference

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

31 March 2020

1 reference

Chromosome transfer activates and delineates a locus control region for perforin.

31 March 2020

1 reference

The transcriptional control of the perforin locus

31 March 2020

1 reference

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

31 March 2020

1 reference

Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

31 March 2020

1 reference

MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1

31 March 2020

1 reference

Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity

31 March 2020

1 reference

MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation

31 March 2020

1 reference

Identification of resting and type I IFN-activated human NK cell miRNomes reveals microRNA-378 and microRNA-30e as negative regulators of NK cell cytotoxicity.

31 March 2020

1 reference

Cathepsin H is an additional convertase of pro-granzyme B

31 March 2020

1 reference

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

31 March 2020

1 reference

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

31 March 2020

1 reference

Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).

31 March 2020

1 reference

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

31 March 2020

1 reference

Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH

31 March 2020

1 reference

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

31 March 2020

1 reference

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes

31 March 2020

1 reference

The structural basis for membrane binding and pore formation by lymphocyte perforin

31 March 2020

1 reference

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

31 March 2020

1 reference

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

31 March 2020

1 reference

Cytotoxic immunological synapses

31 March 2020

1 reference

The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse.

31 March 2020

1 reference

Centrosome polarization delivers secretory granules to the immunological synapse.

31 March 2020

1 reference

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.

31 March 2020

1 reference

A case of partial dedicator of cytokinesis 8 deficiency with altered effector phenotype and impaired CD8⁺ and natural killer cell cytotoxicity.

31 March 2020

1 reference

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

31 March 2020

1 reference

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell

31 March 2020

1 reference

Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation

31 March 2020

1 reference

Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells

31 March 2020

1 reference

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

31 March 2020

1 reference

Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway

31 March 2020

1 reference

Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage

31 March 2020

1 reference

Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

31 March 2020

1 reference

Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules

31 March 2020

1 reference

Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense

31 March 2020

1 reference

A common fold mediates vertebrate defense and bacterial attack

31 March 2020

1 reference

Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit

31 March 2020

1 reference

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

31 March 2020

1 reference

Structural basis of pore formation by the bacterial toxin pneumolysin

31 March 2020

1 reference

Predicting giant transmembrane β-barrel architecture

31 March 2020

1 reference

Membrane pore formation at protein-lipid interfaces

31 March 2020

1 reference

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.

31 March 2020

1 reference

Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

31 March 2020

1 reference

Perforin: structure, function, and role in human immunopathology

31 March 2020

1 reference

The molecular basis for perforin oligomerization and transmembrane pore assembly

31 March 2020

1 reference

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

31 March 2020

1 reference

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

31 March 2020

1 reference

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

31 March 2020

1 reference

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

31 March 2020

1 reference

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

31 March 2020

1 reference

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

31 March 2020

1 reference

Calcium uptake via endocytosis with rapid release from acidifying endosomes.

31 March 2020

1 reference

Perforin rapidly induces plasma membrane phospholipid flip-flop

31 March 2020

1 reference

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

31 March 2020

1 reference

Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes

31 March 2020

1 reference

Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.

31 March 2020

1 reference

Plasma Membrane Disruption: Repair, Prevention, Adaptation

31 March 2020

1 reference

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

31 March 2020

1 reference

Granzyme B in injury, inflammation, and repair

31 March 2020

1 reference

Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

31 March 2020

1 reference

Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans

31 March 2020

1 reference

Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining.

31 March 2020

1 reference

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

31 March 2020

1 reference

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

31 March 2020

1 reference

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

31 March 2020

1 reference

The major human and mouse granzymes are structurally and functionally divergent

31 March 2020

1 reference

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

31 March 2020

1 reference

Human and murine granzyme B exhibit divergent substrate preferences

31 March 2020

1 reference

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

31 March 2020

1 reference

A natural genetic variant of granzyme B confers lethality to a common viral infection

31 March 2020

1 reference

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

31 March 2020

1 reference

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

31 March 2020

1 reference

Human and mouse granzyme A induce a proinflammatory cytokine response.

31 March 2020

1 reference

A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.

31 March 2020

1 reference

Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation

31 March 2020

1 reference

Granzyme M: behind enemy lines

31 March 2020

1 reference

Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis

31 March 2020

1 reference

Functional analysis of granzyme M and its role in immunity to infection

31 March 2020

1 reference

Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state.

31 March 2020

1 reference

Blessing or curse? Proteomics in granzyme research

31 March 2020

1 reference

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

31 March 2020

1 reference

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

31 March 2020

1 reference

Granzyme A is an interleukin 1 beta-converting enzyme

31 March 2020

1 reference

Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice

31 March 2020

1 reference

Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells

31 March 2020

1 reference

Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation

31 March 2020

1 reference

Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication.

31 March 2020

1 reference

A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

31 March 2020

1 reference

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

31 March 2020

1 reference

CD8+ T cell granzyme B activates keratinocyte endogenous IL-18.

31 March 2020

1 reference

Granzyme B is a novel interleukin-18 converting enzyme.

31 March 2020

1 reference

Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes

31 March 2020

1 reference

Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis

31 March 2020

1 reference

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice

31 March 2020

1 reference

Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3

31 March 2020

1 reference

All human granzymes target hnRNP K that is essential for tumor cell viability

31 March 2020

1 reference

FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade

31 March 2020

1 reference

Granzyme M cannot induce cell death via cleavage of mouse FADD.

31 March 2020

1 reference

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

31 March 2020

1 reference

Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells

31 March 2020

1 reference

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

31 March 2020

1 reference

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

31 March 2020

1 reference

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

31 March 2020

1 reference

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

31 March 2020

1 reference

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11

31 March 2020

1 reference

Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11

31 March 2020

1 reference

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

31 March 2020

1 reference

Decreased tumor surveillance in perforin-deficient mice

31 March 2020

1 reference

Perforin dependence of natural killer cell-mediated tumor control in vivo

31 March 2020

1 reference

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

31 March 2020

1 reference

Occurrence of malignancy in immunodeficiency diseases. A literature review

31 March 2020

1 reference

Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation

31 March 2020

1 reference

The biological and chemical basis for tissue-selective amyloid disease

31 March 2020

1 reference

An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

31 March 2020

1 reference

Development of classical Hodgkin's lymphoma in an adult with biallelic STXBP2 mutations

31 March 2020

1 reference

Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2.

31 March 2020

1 reference

Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5).

31 March 2020

1 reference

Cancer risk following organ transplantation: a nationwide cohort study in Sweden

31 March 2020

1 reference

Association of Cancer With AIDS-Related Immunosuppression in Adults

31 March 2020

1 reference

Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis

31 March 2020

1 reference

Enhancement of antitumor immunity by CTLA-4 blockade

31 March 2020

1 reference

Immune checkpoint blockade

31 March 2020

1 reference

Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy

31 March 2020

1 reference

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

31 March 2020

1 reference

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

31 March 2020

1 reference

Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

31 March 2020

1 reference

Human perforin mutations and susceptibility to multiple primary cancers

31 March 2020

1 reference

Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis

31 March 2020

1 reference

Granulysin crystal structure and a structure-derived lytic mechanism

31 March 2020

1 reference

An antimicrobial activity of cytolytic T cells mediated by granulysin

31 March 2020

1 reference

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

31 March 2020

1 reference

Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis

31 March 2020

1 reference

NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network

31 March 2020

1 reference

Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells

31 March 2020

1 reference

Granzyme M mediates a novel form of perforin-dependent cell death

31 March 2020

1 reference

Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation

31 March 2020

1 reference

A new model for pore formation by cholesterol-dependent cytolysins

31 March 2020

1 reference

Discordant regulation of granzyme H and granzyme B expression in human lymphocytes

31 March 2020

1 reference

Atypical features of familial hemophagocytic lymphohistiocytosis.

31 March 2020

1 reference

Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma

31 March 2020

1 reference

Adult onset and atypical presentation of hemophagocytic lymphohistiocytosis in siblings carrying PRF1 mutations

31 March 2020

1 reference

A proportion of patients with lymphoma may harbor mutations of the perforin gene.

31 March 2020

1 reference

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

31 March 2020

1 reference

Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease

31 March 2020

1 reference

Clinical and molecular aspects of Turkish familial hemophagocytic lymphohistiocytosis patients with perforin mutations

31 March 2020

1 reference

Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.

31 March 2020

1 reference

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

31 March 2020

1 reference

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis due to perforin mutations.

31 March 2020

1 reference

Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses

31 March 2020

1 reference

Filtration, diffusion, and molecular sieving through porous cellulose membranes.

31 March 2020

1 reference

12 December 2020

A single amino acid change A91V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?

1 reference

12 December 2020

Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity

1 reference

12 December 2020

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes

1 reference

12 December 2020

Perforin is essential for control of ectromelia virus but not related poxviruses in mice.

1 reference

12 December 2020

Lysis of homologous cells by sensitized lymphocytes in tissue culture.

1 reference

12 December 2020

New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis

1 reference

12 December 2020

Familial hemophagocytic lymphohistiocytosis in an adult patient homozygous for A91V in the perforin gene, with tuberculosis infection

1 reference

12 December 2020

Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography

1 reference

12 December 2020

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes

1 reference

12 December 2020

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors

1 reference

12 December 2020

Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins

1 reference

12 December 2020

Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3839

1 reference

3 September 2017

1 reference

PubMed ID

25998963