(Q40485512)

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Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

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Europe PubMed Central

PubMed publication ID

20 September 2017

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491. (English)

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Europe PubMed Central

PubMed publication ID

20 September 2017

6

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Europe PubMed Central

PubMed publication ID

20 September 2017

Joseph A. Trapani

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Joseph A Trapani

7

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Ilia Voskoboinik

1

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Europe PubMed Central

PubMed publication ID

20 September 2017

Marie-Claude Thia

2

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Europe PubMed Central

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20 September 2017

Jamie Fletcher

3

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Europe PubMed Central

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20 September 2017

Annette Ciccone

4

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Europe PubMed Central

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20 September 2017

Kylie Browne

5

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Europe PubMed Central

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20 September 2017

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publication date

2 December 2004

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Europe PubMed Central

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20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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20 September 2017

280

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Europe PubMed Central

PubMed publication ID

20 September 2017

9

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Europe PubMed Central

PubMed publication ID

20 September 2017

8426-8434

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Functional significance of the perforin/granzyme cell death pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Delivering the kiss of death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Channel-forming activity of the perforin N-terminus and a putative alpha-helical region homologous with complement C9.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Homology of perforin to the ninth component of complement (C9).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Liposomes as targets for granule cytolysin from cytotoxic large granular lymphocyte tumors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

The C2 domain calcium-binding motif: structural and functional diversity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Crystal structure of the C2 domain from protein kinase C-δ

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

JPred: a consensus secondary structure prediction server

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Empirical relationships between protein structure and carboxyl pKa values in proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Granzyme M mediates a novel form of perforin-dependent cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Ca2+ Signaling Modulates Cytolytic T Lymphocyte Effector Functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Novel perforin mutation in a patient with hemophagocytic lymphohistiocytosis and CD45 abnormal splicing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413303200

21 January 2018

Identifiers

10.1074/JBC.M413303200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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