(Q34615774)

3 August 2017

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title

Perforin deficiency and susceptibility to cancer (English)

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3 August 2017

A J Brennan

1

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3 August 2017

J Chia

series ordinal

2

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3 August 2017

J A Trapani

series ordinal

3

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3 August 2017

I Voskoboinik

series ordinal

4

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3 August 2017

language of work or name

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15 January 2010

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Cell Death & Differentiation

3 August 2017

published in

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3 August 2017

volume

17

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3 August 2017

issue

4

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3 August 2017

page(s)

607-615

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https://scigraph.springernature.com/pub.10.1038/cdd.2009.212

3 August 2017

exact match

0 references

cites work

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Functional significance of the perforin/granzyme cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin-mediated target-cell death and immune homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Chromosome transfer activates and delineates a locus control region for perforin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Homology of perforin to the ninth component of complement (C9).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Structure and function of human perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Liposomes as targets for granule cytolysin from cytotoxic large granular lymphocyte tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

The MACPF/CDC family of pore-forming toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A common fold mediates vertebrate defense and bacterial attack

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

The molecular basis for perforin oligomerization and transmembrane pore assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Immune function in mice lacking the perforin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Decreased tumor surveillance in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Adaptive immunity maintains occult cancer in an equilibrium state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Familial hemophagocytic lymphohistiocytosis. Clinical review based on the findings in seven children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Familial and acquired hemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Hemophagocytic lymphohistiocytosis and other hemophagocytic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis due to perforin mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Characteristic perforin gene mutations of haemophagocytic lymphohistiocytosis patients in Japan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A proportion of patients with lymphoma may harbor mutations of the perforin gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Significant role for Fas in the pathogenesis of autoimmune diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

The complex issue of regulating perforin expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Variations of the perforin gene in patients with autoimmunity/lymphoproliferation and defective Fas function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

7 January 2021

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

7 January 2021

Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

7 January 2021

Perforin A91V polymorphism and putative susceptibility to hematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

7 January 2021

Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

7 January 2021

Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

7 January 2021

Variations of the perforin gene in patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.212

7 January 2021

Identifiers

DOI

10.1038/CDD.2009.212

1 reference

Dimensions Publication ID

3 August 2017

1012467921

0 references

1 reference