(Q34584322)

3 August 2017

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title

Perforin-mediated target-cell death and immune homeostasis (English)

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3 August 2017

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Joseph A Trapani

3

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Mark J. Smyth

object named as

Mark J Smyth

series ordinal

2

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author name string

Ilia Voskoboinik

series ordinal

1

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3 August 2017

publication date

1 December 2006

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

6

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3 August 2017

issue

12

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3 August 2017

page(s)

940-952

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

3 August 2017

cites work

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Decreased tumor surveillance in perforin-deficient mice

21 January 2018

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Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses

21 January 2018

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Perforin and lymphohistiocytic proliferative disorders.

21 January 2018

1 reference

Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis

21 January 2018

1 reference

Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis

21 January 2018

1 reference

Granzyme B: pro-apoptotic, antiviral and antitumor functions

21 January 2018

1 reference

Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator

21 January 2018

1 reference

A pore-forming protein, perforin, from a non-mammalian organism, Japanese flounder, Paralichthys olivaceus

21 January 2018

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Functional significance of the perforin/granzyme cell death pathway

21 January 2018

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

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A central role for Bid in granzyme B-induced apoptosis

21 January 2018

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Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

21 January 2018

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Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

21 January 2018

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Nuclear war: the granzyme A-bomb

21 January 2018

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HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

21 January 2018

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Cell death induced by granzyme C.

21 January 2018

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Granzyme M mediates a novel form of perforin-dependent cell death

21 January 2018

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

21 January 2018

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Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

21 January 2018

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An emergency response team for membrane repair

21 January 2018

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Coping with the inevitable: how cells repair a torn surface membrane

21 January 2018

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Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes

21 January 2018

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Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

21 January 2018

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Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

21 January 2018

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Identification and characterization of a pore-forming protein of human peripheral blood natural killer cells

21 January 2018

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Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

21 January 2018

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The pore-forming protein (perforin) of cytolytic T lymphocytes is immunologically related to the components of membrane attack complex of complement through cysteine-rich domains

21 January 2018

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Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules

21 January 2018

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Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).

21 January 2018

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Structure and function of human perforin

21 January 2018

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The lymphocyte pore-forming protein perforin is associated with granules by a pH-dependent mechanism

21 January 2018

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Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

21 January 2018

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Perforin binding to cells and lipid membranes determined by a simple competition assay

21 January 2018

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Membrane channel formation by the lymphocyte pore-forming protein: comparison between susceptible and resistant target cells

21 January 2018

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Perforin: structure and function

21 January 2018

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The C2 domain calcium-binding motif: structural and functional diversity

21 January 2018

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Crystal structure of the C2 domain from protein kinase C-delta

21 January 2018

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Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

21 January 2018

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Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

21 January 2018

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Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

21 January 2018

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Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation

21 January 2018

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Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells

21 January 2018

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Incidence in Sweden and clinical features of familial hemophagocytic lymphohistiocytosis

21 January 2018

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Familial and acquired hemophagocytic lymphohistiocytosis

21 January 2018

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Familial haemophagocytic reticulosis

21 January 2018

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Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

21 January 2018

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Six novel mutations in the PRF1 gene in children with haemophagocytic lymphohistiocytosis

21 January 2018

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Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

21 January 2018

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Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis

21 January 2018

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Localization of a gene for familial hemophagocytic lymphohistiocytosis at chromosome 9q21.3-22 by homozygosity mapping

21 January 2018

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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

21 January 2018

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Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

21 January 2018

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Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences

21 January 2018

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Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11

21 January 2018

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Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A

21 January 2018

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Occurrence of haemophagocytic lymphohistiocytosis at less than 1 year of age: analysis of 96 patients

21 January 2018

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An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

21 January 2018

1 reference

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis.

21 January 2018

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A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

21 January 2018

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The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

21 January 2018

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Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.

21 January 2018

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A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype

21 January 2018

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Atypical features of familial hemophagocytic lymphohistiocytosis.

21 January 2018

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Immune surveillance of lymphoma in humans?

21 January 2018

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A proportion of patients with lymphoma may harbor mutations of the perforin gene.

21 January 2018

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Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

21 January 2018

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Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

21 January 2018

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Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus

21 January 2018

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Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity

21 January 2018

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Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liver

21 January 2018

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CD8-mediated protection against Ebola virus infection is perforin dependent

21 January 2018

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Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

21 January 2018

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NK cells use perforin rather than granulysin for anticryptococcal activity.

21 January 2018

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Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

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Influence of effector molecules on the CD8(+) T cell response to infection

21 January 2018

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Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

21 January 2018

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Suppression of lymphoma and epithelial malignancies effected by interferon gamma

21 January 2018

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Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

21 January 2018

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Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas

21 January 2018

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IL-21 induces the functional maturation of murine NK cells

21 January 2018

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Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

21 January 2018

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Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

21 January 2018

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

21 January 2018

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

21 January 2018

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Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8.

21 January 2018

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Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation

21 January 2018

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Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL).

21 January 2018

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Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity

21 January 2018

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Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome

21 January 2018

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Identification of the homologous beige and Chediak-Higashi syndrome genes

21 January 2018

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Clinical, molecular, and cell biological aspects of Chediak-Higashi syndrome

21 January 2018

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Lytic granules, secretory lysosomes and disease

21 January 2018

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Delivering the kiss of death

21 January 2018

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A syndrome associating partial albinism and immunodeficiency

21 January 2018

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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

21 January 2018

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

21 January 2018

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X-linked recessive progressive combined variable immunodeficiency (Duncan's disease)

21 January 2018

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SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

21 January 2018

1 reference

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

21 January 2018

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Hemophagocytic lymphohistiocytosis due to germline mutations in SH2D1A, the X-linked lymphoproliferative disease gene

21 January 2018

1 reference

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

21 January 2018

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Functional analysis of granzyme M and its role in immunity to infection

21 January 2018

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

21 January 2018

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

21 January 2018

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Autoimmune Lymphoproliferative Syndrome and Perforin

21 January 2018

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Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis

21 January 2018

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A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

21 January 2018

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Variations of the perforin gene in patients with autoimmunity/lymphoproliferation and defective Fas function

21 January 2018

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The hole truth about perforin

21 January 2018

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Familial hemophagocytic lymphohistiocytosis

21 January 2018

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Cytotoxic T lymphocytes: all roads lead to death

31 March 2020

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Dual mechanisms of apoptosis induction by cytotoxic lymphocytes.

31 March 2020

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Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells

31 March 2020

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The primary structure of the lymphocyte pore-forming protein perforin: partial amino acid sequencing and determination of isoelectric point

31 March 2020

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Negative cooperativity exhibited by the lytic amino-terminal domain of human perforin: implications for perforin-mediated cell lysis

31 March 2020

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Solution structure of a synthetic lytic peptide: the perforin amino terminus

31 March 2020

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Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions

31 March 2020

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Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice

31 March 2020

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Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation

31 March 2020

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Adult onset and atypical presentation of hemophagocytic lymphohistiocytosis in siblings carrying PRF1 mutations

31 March 2020

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Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

31 March 2020

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Homeostatic regulation of CD8+ T cells by perforin

31 March 2020

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Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

31 March 2020

1 reference

Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members

31 March 2020

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A molecular genetic linkage map of mouse chromosome 19, including thelpr, Ly-44, andTdt genes

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1983

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3 August 2017

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