(Q38822173)

26535007

6 September 2017

title

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. (English)

1 reference

6 September 2017

9

1 reference

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6 June 2020

David P. Kelsell

18

1 reference

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6 June 2020

17

Garry P Nolan

1 reference

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6 June 2020

14

Carsten Münk

1 reference

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6 June 2020

15

Dieter Häussinger

1 reference

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6 June 2020

author name string

Sathish K Maney

1

1 reference

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6 June 2020

David R McIlwain

2

1 reference

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6 June 2020

Robin Polz

3

1 reference

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6 June 2020

Aleksandra A Pandyra

4

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6 June 2020

Balamurugan Sundaram

5

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6 June 2020

Dorit Wolff

6

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6 June 2020

Kazuhito Ohishi

7

1 reference

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6 June 2020

Thorsten Maretzky

8

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6 June 2020

Astrid Evers

10

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6 June 2020

Ananda A Jaguva Vasudevan

11

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6 June 2020

Nima Aghaeepour

12

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6 June 2020

Jürgen Scheller

13

1 reference

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6 June 2020

Tak W Mak

16

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6 June 2020

Carl P Blobel

19

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6 June 2020

Karl S Lang

20

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6 June 2020

Philipp A Lang

21

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6 June 2020

publication date

3 November 2015

1 reference

6 September 2017

1 reference

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6 June 2020

volume

8

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6 June 2020

issue

401

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6 June 2020

page(s)

ra109

1 reference

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ADAMs: key components in EGFR signalling and development

6 June 2020

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21 January 2018

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Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme

21 January 2018

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

21 January 2018

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Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

21 January 2018

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

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iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

21 January 2018

1 reference

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Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

21 January 2018

1 reference

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iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

21 January 2018

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iRhom2 is required for the secretion of mouse TNFα

21 January 2018

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iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

21 January 2018

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RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome

21 January 2018

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iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function

21 January 2018

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Rhomboid proteins: a role in keratinocyte proliferation and cancer.

21 January 2018

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Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice.

21 January 2018

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Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

21 January 2018

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

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Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells

21 January 2018

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TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

21 January 2018

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Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries

21 January 2018

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Inhibition of death receptor signals by cellular FLIP

21 January 2018

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Proteomic analysis of differentially expressed skin proteins in iRhom2(Uncv) mice

21 January 2018

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New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.

21 January 2018

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Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

21 January 2018

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Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

21 January 2018

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Caspase functions in cell death and disease

21 January 2018

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Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

21 January 2018

1 reference

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Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

21 January 2018

1 reference

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The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

21 January 2018

1 reference

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Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.

21 January 2018

1 reference

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Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

21 January 2018

1 reference

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ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

21 January 2018

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Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.

21 January 2018

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Insights into desmosome biology from inherited human skin disease and cardiocutaneous syndromes.

21 January 2018

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Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer

21 January 2018

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ADAMs in cancer cell proliferation and progression.

21 January 2018

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iRhom2 mutation leads to aberrant hair follicle differentiation in mice

21 January 2018

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Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme

21 January 2018

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Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands

21 January 2018

1 reference

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Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells

21 January 2018

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Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

21 January 2018

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A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.

21 January 2018

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IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.

21 January 2018

1 reference

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Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

21 January 2018

1 reference

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iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26535007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26535007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An essential role for ectodomain shedding in mammalian development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26535007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.AAC5356

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26535007%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26535007%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

26535007

1 reference