(Q38843608)

English

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

scientific article published on 11 July 2016

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scholarly article

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Europe PubMed Central

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6 September 2017

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1. (English)

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Europe PubMed Central

PubMed publication ID

6 September 2017

phosphorylation

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Bernhard Lüscher

20

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6 September 2017

Mathias Heikenwalder

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Mathias Heikenwalder

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Michael Karin

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6 September 2017

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Luca Quagliata

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Ralf Weiskirchen

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Ralf Weiskirchen

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Christiane Koppe

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6 September 2017

Patricia Verheugd

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6 September 2017

Jérémie Gautheron

3

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6 September 2017

Florian Reisinger

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Karina Kreggenwinkel

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Christoph Roderburg

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Luigi Terracciano

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Nikolaus Gassler

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René H Tolba

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Yannick Boege

11

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Achim Weber

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Mark Luedde

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Ulf P Neumann

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Frank Tacke

17

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Mihael Vucur

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Christian Trautwein

19

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Christian Preisinger

21

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6 September 2017

Tom Luedde

23

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6 September 2017

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publication date

11 July 2016

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6 September 2017

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6 September 2017

64

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1217-1231

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6 September 2017

Management of hepatocellular carcinoma: An update

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Inflammation meets cancer, with NF-κB as the matchmaker

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Regulation and function of IKK and IKK-related kinases

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Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation

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Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

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Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

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The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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The 'complexities' of life and death: death receptor signalling platforms

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Death receptor signal transducers: nodes of coordination in immune signaling networks

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Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

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TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.

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TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

1 reference

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IKKalpha is required to maintain skin homeostasis and prevent skin cancer.

1 reference

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

1 reference

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Hepatocyte-specific expression of Cre recombinase

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

1 reference

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Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

1 reference

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21 January 2018

IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

1 reference

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21 January 2018

Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro.

1 reference

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Cell death and cell death responses in liver disease: mechanisms and clinical relevance

1 reference

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RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation

1 reference

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21 January 2018

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

1 reference

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21 January 2018

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

1 reference

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21 January 2018

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

1 reference

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21 January 2018

The two faces of receptor interacting protein kinase-1

1 reference

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21 January 2018

Cell-type-resolved quantitative proteomics of murine liver

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

gammaH2AX: a sensitive molecular marker of DNA damage and repair

1 reference

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21 January 2018

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis

1 reference

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21 January 2018

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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21 January 2018

Identification of RIP1 kinase as a specific cellular target of necrostatins

1 reference

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21 January 2018

Signaling to NF-kappaB

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

Contradictory functions of NF-kappaB in liver physiology and cancer

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.

1 reference

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21 January 2018

The microbiome and cancer

1 reference

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21 January 2018

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28723

21 January 2018

Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation

1 reference

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21 January 2018

Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

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21 January 2018

DNA damage sensor γ -H2AX is increased in preneoplastic lesions of hepatocellular carcinoma

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Identifiers

10.1002/HEP.28723

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

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