(Q38861412)

7 September 2017

ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer (English)

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7 September 2017

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A Latina

1

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7 September 2017

G Viticchiè

2

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7 September 2017

A M Lena

3

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7 September 2017

M C Piro

4

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7 September 2017

M Annicchiarico-Petruzzelli

5

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7 September 2017

G Melino

6

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7 September 2017

E Candi

7

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7 September 2017

language of work or name

English

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publication date

22 June 2015

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7 September 2017

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7 September 2017

35

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7 September 2017

12

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7 September 2017

1493-1503

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https://scigraph.springernature.com/pub.10.1038/onc.2015.222

7 September 2017

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cites work

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

TAp63 and DeltaNp63 in cancer and epidermal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63, a story of mice and men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 in epithelial survival, germ cell surveillance, and neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 protein is essential for the embryonic development of vibrissae and teeth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 in epithelial development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 is upstream of IKK alpha in epidermal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 Is essential for the proliferative potential of stem cells in stratified epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 regulates proliferation and differentiation of developmentally mature keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

The p63 target HBP1 is required for skin differentiation and stratification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 regulates an adhesion programme and cell survival in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Perp is a p63-regulated gene essential for epithelial integrity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Oxidative stress and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Oxidative stress in the pathogenesis of skin disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Structure and function evolution in the superfamily of globins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

DNA damage induced activation of Cygb stabilizes p53 and mediates G1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Protection from ischemic cell death by the induction of cytoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63-microRNA feedback in keratinocyte senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p51/p63 Inhibits ultraviolet B-induced apoptosis via Akt activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

21 January 2018

The genetics of ageing

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Mitochondria, oxidants, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Living on a break: cellular senescence as a DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

TAp73 depletion accelerates aging through metabolic dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Identification of NCF2/p67phox as a novel p53 target gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Cystathionase mediates senescence evasion in melanocytes and melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12) and maintains ERK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

SATB1 collaborates with loss of p16 in cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Zinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Regulation of skin aging and heart development by TAp63.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p63 deficiency activates a program of cellular senescence and leads to accelerated aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Loss of heterozygosity and transcriptome analyses of a 1.2 Mb candidate ovarian cancer tumor suppressor locus region at 17q25.1-q25.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

A model for p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

The antioxidant function of the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Regulation of AIF expression by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Metabolic regulation by p53 family members.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Caspase-1 is a novel target of p63 in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

p73 regulates serine biosynthesis in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Characterization of human cytoglobin gene promoter region

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.222

Overexpression of cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells

31 March 2020

1 reference

12 December 2020

Protective effects of N-acetylcysteine and selenium against doxorubicin toxicity in rats

1 reference

12 December 2020

Down-regulation of p63 is required for epidermal UV-B-induced apoptosis

1 reference

12 December 2020

Significance of p63 amplification and overexpression in lung cancer development and prognosis.

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2015.222

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Dimensions Publication ID

7 September 2017

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