(Q38911597)

7 September 2017

title

Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer (English)

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7 September 2017

6

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7 September 2017

Iris Eke

1

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Nils Cordes

object named as

Nils Cordes

8

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Mechthild Krause

object named as

Mechthild Krause

7

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Katja Zscheppang

2

object named as

Katja Zscheppang

1 reference

7 September 2017

3

Ellen Dickreuter

1 reference

7 September 2017

Linda Hickmann

4

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7 September 2017

Ercole Mazzeo

5

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7 September 2017

language of work or name

English

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publication date

5 February 2015

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Journal of the National Cancer Institute

7 September 2017

published in

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7 September 2017

volume

107

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7 September 2017

issue

2

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Hallmarks of Cancer: The Next Generation

7 September 2017

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1 reference

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Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival

21 January 2018

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Integrins as novel drug targets for overcoming innate drug resistance.

21 January 2018

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Integrins in cancer: biological implications and therapeutic opportunities

21 January 2018

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beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

21 January 2018

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Combating resistance to anti-IGFR antibody by targeting the integrin β3-Src pathway

21 January 2018

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ErbB receptors and signaling pathways in cancer

21 January 2018

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Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression

21 January 2018

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Dual targeting of EGFR and focal adhesion kinase in 3D grown HNSCC cell cultures

21 January 2018

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EGFR/JIP-4/JNK2 signaling attenuates cetuximab-mediated radiosensitization of squamous cell carcinoma cells

21 January 2018

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Cetuximab attenuates its cytotoxic and radiosensitizing potential by inducing fibronectin biosynthesis

21 January 2018

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Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

21 January 2018

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Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer.

21 January 2018

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Understanding resistance to EGFR inhibitors-impact on future treatment strategies

21 January 2018

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Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family

21 January 2018

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Integrin regulation of growth factor receptors

21 January 2018

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Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

21 January 2018

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Molecular interactions of ErbB1 (EGFR) and integrin-β1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance

21 January 2018

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β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells

21 January 2018

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Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

21 January 2018

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Increased beta1 integrin is associated with decreased survival in invasive breast cancer

21 January 2018

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New roles for integrins in squamous-cell carcinoma

21 January 2018

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beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.

21 January 2018

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Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

21 January 2018

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β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

21 January 2018

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Integrins: bidirectional, allosteric signaling machines

21 January 2018

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21 January 2018

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Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

21 January 2018

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Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails

21 January 2018

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Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics

21 January 2018

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Integrin-regulated FAK-Src signaling in normal and cancer cells

21 January 2018

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FERM control of FAK function: implications for cancer therapy.

21 January 2018

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Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis

21 January 2018

1 reference

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Targeting FAK radiosensitizes 3-dimensional grown human HNSCC cells through reduced Akt1 and MEK1/2 signaling

21 January 2018

1 reference

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Expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma.

21 January 2018

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PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha

21 January 2018

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Three-dimensional cell growth confers radioresistance by chromatin density modification

21 January 2018

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Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'

21 January 2018

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21 January 2018

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Integration of biological networks and gene expression data using Cytoscape

21 January 2018

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KEGG: kyoto encyclopedia of genes and genomes

21 January 2018

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Integrative radiation systems biology.

21 January 2018

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Bypassing cancer drug resistance by activating multiple death pathways--a proposal from the study of circumventing cancer drug resistance by induction of necroptosis

21 January 2018

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Ligand-triggered resistance to molecular targeted drugs in lung cancer: roles of hepatocyte growth factor and epidermal growth factor receptor ligands

21 January 2018

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The molecular basis of targeting protein kinases in cancer therapeutics

21 January 2018

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How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

21 January 2018

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Erlotinib resistance in lung cancer cells mediated by integrin β1/Src/Akt-driven bypass signaling.

21 January 2018

1 reference

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Network quantification of EGFR signaling unveils potential for targeted combination therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJU419

Inhibition of both EGFR and IGF1R sensitized prostate cancer cells to radiation by synergistic suppression of DNA homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJU419

p53 modulates acquired resistance to EGFR inhibitors and radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJU419

Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJU419

Integrin engagement increases histone H3 acetylation and reduces histone H1 association with DNA in murine lung endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJU419

Base excision repair proteins are required for integrin-mediated suppression of bleomycin-induced DNA breakage in murine lung endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJU419

EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJU419

21 January 2018

Identifiers

DOI

10.1093/JNCI/DJU419

1 reference

7 September 2017

1 reference