(Q38945423)

8 January 2018

review article

1 reference

title

Gut microbiome interactions with drug metabolism, efficacy, and toxicity (English)

1 reference

8 January 2018

0 references

1 reference

2

Jeremy K Nicholson

1 reference

8 January 2018

author name string

Ian D Wilson

series ordinal

1

1 reference

8 January 2018

publication date

13 August 2016

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8 January 2018

published in

Translational Research

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8 January 2018

volume

179

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8 January 2018

page(s)

204-222

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8 January 2018

3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2.

cites work

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A comparison of the gut microbiome between long-term users and non-users of proton pump inhibitors.

17 June 2018

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Proton pump inhibitors alter the composition of the gut microbiota

17 June 2018

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Bidirectional interactions between indomethacin and the murine intestinal microbiota

17 June 2018

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Proton pump inhibitors affect the gut microbiome

17 June 2018

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Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics

17 June 2018

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The Inhibitory Effect of Ciprofloxacin on the β-Glucuronidase-mediated Deconjugation of the Irinotecan Metabolite SN-38-G.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The influence of non-steroidal anti-inflammatory drugs on the gut microbiome

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

17 June 2018

1 reference

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Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids

17 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Drug Metabolism by the Host and Gut Microbiota: A Partnership or Rivalry?

17 June 2018

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Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Nonsteroidal anti-inflammatory drugs, proton pump inhibitors, and gastrointestinal injury: contrasting interactions in the stomach and small intestine.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Prolonged use of a proton pump inhibitor reduces microbial diversity: implications for Clostridium difficile susceptibility

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Eradication of Helicobacter pylori infection improves levodopa action, clinical symptoms and quality of life in patients with Parkinson's disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Gut microbiota-mediated drug interactions between lovastatin and antibiotics

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Old drug new use--amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The effect of gut microbiota on drug metabolism

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Cometabolism of microbes and host: implications for drug metabolism and drug-induced toxicity.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Xenobiotics and the human gut microbiome: metatranscriptomics reveal the active players

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Xenobiotics shape the physiology and gene expression of the active human gut microbiome

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Role of intestinal microflora in xenobiotic-induced toxicity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Therapeutic modulation of microbiota-host metabolic interactions.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Host-gut microbiota metabolic interactions

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Colonization-induced host-gut microbial metabolic interaction

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Long-term impacts of antibiotic exposure on the human intestinal microbiota

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Intestinal microbiota regulate xenobiotic metabolism in the liver

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The effect of proton pump inhibitors on the human microbiota

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Gut microorganisms, mammalian metabolism and personalized health care

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The challenges of modeling mammalian biocomplexity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Bioactive isoflavones in functional foods: the importance of gut microflora on bioavailability

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Molecular analysis of commensal host-microbial relationships in the intestine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Urinary excretion of reduced metabolites of digoxin

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Techniques for microfloral and associated metabolic studies in relation to the absorption and enterohepatic circulation of drugs

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The metabolism of orally administered l-DOPA in Parkinsonism

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Therapeutic Implications in Parkinsonism of m-Tyramine Formation from L-Dopa in Man

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Contributions of host and intestinal microflora in the metabolism of L-dopa by the rat.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Metabolism of N-acylated and O-alkylated drugs by the intestinal microflora during anaerobic incubation in vitro.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The demethylation of methamphetamine by intestinal microflora

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The influence of the host on expression of intestinal microbial enzyme activities involved in metabolism of foreign compounds.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Digoxin inactivation by the gut flora in infancy and childhood.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Anaerobic metabolism of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) by human fecal flora

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Role of intestinal flora in metabolism of agrochemicals conjugated with glutathione

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Mutagen activation by hepatic fractions from conventional, germfree and monoassociated rats.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

17 June 2018

Evolution of olsalazine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Role of the intestinal flora in the acetylation of sulfasalazine metabolites

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Chloramphenicol toxicity: 25 years of research.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Involvement of the intestinal microflora in nitrazepam-induced teratogenicity in rats and its relationship to nitroreduction

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Reductive metabolism of the anticonvulsant agent zonisamide, a 1,2-benzisoxazole derivative

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The role of intestinal bacteria in the transformation of sodium picosulfate

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The anaerobic metabolism of metronidazole forms N-(2-hydroxyethyl)-oxamic acid

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Acetamide—a metabolite of metronidazole formed by the intestinal flora

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Influence of Gut Microflora on Bioavailability

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Discovery of specific inhibitors for intestinal E. coli β-glucuronidase through in silico virtual screening.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Investigations of hydrazine cleavage of eltrombopag in humans.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Intestinal flora induces the expression of Cyp3a in the mouse liver

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Optimal antidiarrhea treatment for antitumor agent irinotecan hydrochloride (CPT-11)-induced delayed diarrhea

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

An in vitro study on the active conversion of flucytosine to fluorouracil by microorganisms in the human intestinal microflora.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Colonic metabolism of ranitidine: implications for its delivery and absorption

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Soy consumption alters endogenous estrogen metabolism in postmenopausal women.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

The Role of the Gut Flora in the Metabolism of Prontosil and Neoprontosil in the Rat

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Is It Time for a Metagenomic Basis of Therapeutics?

1 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5718288

Intestinal azo-reduction and glucuronide conjugation of prontosil

2 December 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Azo reduction of salicyl-azo-sulphapyridine in germ-free and conventional rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Role of the intestinal microflora in clonazepam metabolism in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Degradation of bromazepam by the intestinal microflora

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

The bacterial degradation of chloramphenicol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Role of the intestinal flora in the metabolism of misonidazole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Intestinal microflora as potential modifiers of sensitizer activity in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Site dependent bioavailability and metabolism of levosimendan in dogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

The reduction of sulphinpyrazone and sulindac by intestinal bacteria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Metabolism of Omeprazole by Gut Flora in Rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Digoxin-inactivating bacteria: identification in human gut flora

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Degradation of DOPA by Intestinal Microorganisms in Vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Dosage form design for improvement of bioavailability of levodopa IV: Possible causes of low bioavailability of oral levodopa in dogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Antibiotics alter methotrexate metabolism and excretion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Studies of the metabolism of methotrexate by intestinal flora. I. Identification and study of biological properties of the metabolite 4-amino-4-deoxy-N 10 -methylpteroic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Metabolism of peptide drugs by the microorganisms in rat cecal contents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: implications in peptide delivery to the colon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Development of an oral formulation of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, using n-lauryl-beta-D-maltopyranoside as an absorption enhancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

The role of intestinal microflora in the formation of the methylthio adduct metabolites of paracetamol. Studies in neomycin-pretreated and germ-free mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Pancreatitis Associated with Olsalazine and Sulfasalazine in Children with Ulcerative Colitis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2016.08.002

Colonisation with digoxin-reducing strains of Eubacterium lentum and Clostridium difficile infection in nursing home patients

7 January 2021

1 reference

12 December 2020

Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats

1 reference

12 December 2020

The metabolism and excretion of risperidone after oral administration in rats and dogs

1 reference

12 December 2020

Inactivation of digoxin by Eubacterium lentum, an anaerobe of the human gut flora

1 reference

12 December 2020

Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans

1 reference

12 December 2020

Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats

1 reference

12 December 2020

The role of intestinal bacteria in the metabolism of salicylazosulfapyridine

1 reference

12 December 2020

Differences between germ-free and conventional rats in liver microsomal metabolism of steroids

1 reference

12 December 2020

In-vitro interaction of L-dopa with bacterial adhesins of Helicobacter pylori: an explanation for clinicial differences in bioavailability?

1 reference

12 December 2020

Chloramphenicol-induced bone marrow injury: possible role of bacterial metabolites of chloramphenicol

1 reference

12 December 2020

A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs

1 reference

12 December 2020

10.1016/J.TRSL.2016.08.002

Identifiers

DOI

1 reference

8 January 2018

PMC publication ID

5718288

1 reference

8 January 2018

PubMed publication ID

27591027

1 reference

8 January 2018