(Q38956580)

7 September 2017

title

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation (English)

1 reference

7 September 2017

1 reference

1 reference

Ioscani Jimenez Del Val

object named as

Ioscani Jimenez Del Val

2

0 references

Cleo Kontoravdi

object named as

Cleo Kontoravdi

6

0 references

Mikael Rørdam Andersen

object named as

Mikael Rørdam Andersen

8

0 references

author name string

Yuzhou Fan

1

1 reference

7 September 2017

Christian Müller

3

1 reference

7 September 2017

Jette Wagtberg Sen

4

1 reference

7 September 2017

Søren Kofoed Rasmussen

5

1 reference

7 September 2017

Dietmar Weilguny

7

1 reference

7 September 2017

language of work or name

1 reference

10 October 2014

1 reference

Biotechnology and Bioengineering

7 September 2017

published in

1 reference

7 September 2017

volume

112

1 reference

7 September 2017

issue

3

1 reference

7 September 2017

page(s)

521-535

1 reference

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

7 September 2017

cites work

1 reference

Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells.

21 January 2018

1 reference

Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control

21 January 2018

1 reference

Considerations on the lactate consumption by CHO cells in the presence of galactose

21 January 2018

1 reference

Improvement of CHO cell culture medium formulation: simultaneous substitution of glucose and glutamine

21 January 2018

1 reference

Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium

21 January 2018

1 reference

Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells

21 January 2018

1 reference

Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-I by chinese hamster ovary cells in a pH-dependent manner

21 January 2018

1 reference

Immunology. Sugar determines antibody activity

21 January 2018

1 reference

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition

21 January 2018

1 reference

Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures.

21 January 2018

1 reference

Effects of amino acid additions on ammonium stressed CHO cells

21 January 2018

1 reference

Metabolic shifts by nutrient manipulation in continuous cultures of BHK cells

21 January 2018

1 reference

Metabolic analysis of antibody producing CHO cells in fed-batch production

21 January 2018

1 reference

Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture

21 January 2018

1 reference

Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells

21 January 2018

1 reference

Quality control in the endoplasmic reticulum

21 January 2018

1 reference

Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells

21 January 2018

1 reference

Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling

21 January 2018

1 reference

High-end pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO fed-batch cultures.

21 January 2018

1 reference

Alteration of cellular metabolism by consecutive fed-batch cultures of mammalian cells

21 January 2018

1 reference

Ammonium alters N-glycan structures of recombinant TNFR-IgG: degradative versus biosynthetic mechanisms

21 January 2018

1 reference

Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.

21 January 2018

1 reference

The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties

21 January 2018

1 reference

CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation

21 January 2018

1 reference

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

21 January 2018

1 reference

Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells

21 January 2018

1 reference

Optimal and consistent protein glycosylation in mammalian cell culture

21 January 2018

1 reference

Maximizing productivity of CHO cell‐based fed‐batch culture using chemically defined media conditions and typical manufacturing equipment

21 January 2018

1 reference

Sialylation of human IgG-Fc carbohydrate by transfected rat alpha2,6-sialyltransferase.

21 January 2018

1 reference

Antibody therapeutics: isotype and glycoform selection

21 January 2018

1 reference

Glycosylation as a strategy to improve antibody-based therapeutics

21 January 2018

1 reference

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

21 January 2018

1 reference

Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns

21 January 2018

1 reference

An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells.

21 January 2018

1 reference

Quantification of intracellular nucleotide sugars and formulation of a mathematical model for prediction of their metabolism

21 January 2018

1 reference

Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC.

21 January 2018

1 reference

Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

1 reference

Influence of intracellular nucleotide and nucleotide sugar contents on recombinant interferon-gamma glycosylation during batch and fed-batch cultures of CHO cells

21 January 2018

1 reference

Assembly of asparagine-linked oligosaccharides

21 January 2018

1 reference

Feeding lactate for CHO cell culture processes: impact on culture metabolism and performance

21 January 2018

1 reference

The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody.

21 January 2018

1 reference

Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults.

21 January 2018

1 reference

Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA.

21 January 2018

1 reference

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

21 January 2018

1 reference

Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24.

21 January 2018

1 reference

Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells

21 January 2018

1 reference

Systems biotechnology of mammalian cell factories

21 January 2018

1 reference

Effects of cell culture conditions on antibody N-linked glycosylation--what affects high mannose 5 glycoform

21 January 2018

1 reference

Metabolic flux analysis in mammalian cell culture

21 January 2018

1 reference

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

21 January 2018

1 reference

Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases

21 January 2018

1 reference

Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO(2).

21 January 2018

1 reference

Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production.

21 January 2018

1 reference

Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein.

21 January 2018

1 reference

Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors

21 January 2018

1 reference

Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

21 January 2018

1 reference

Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells

21 January 2018

1 reference

Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.

21 January 2018

1 reference

Biopharmaceutical benchmarks 2006.

21 January 2018

1 reference

Profiling of N-glycosylation gene expression in CHO cell fed-batch cultures

21 January 2018

1 reference

An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding

21 January 2018

1 reference

Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells

21 January 2018

1 reference

Variations in oligosaccharide-protein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides

21 January 2018

1 reference

Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0 degrees C.

21 January 2018

1 reference

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BIT.25450

1 reference

7 September 2017

1 reference