(Q38958030)

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Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy

scientific article published on 27 August 2014

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scholarly article

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Europe PubMed Central

PMC publication ID

8 September 2017

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy (English)

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

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inferred from title

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Rachel Doherty

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Devika Agarwal

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Paul Moseley

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Claire Seedhouse

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Claire Seedhouse

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Stephen Chan

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Srinivasan Madhusudan

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Srinivasan Madhusudan

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Emad A Rakha

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Andrew Green

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Ian O Ellis

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object named as

Carlos Caldas

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Europe PubMed Central

PMC publication ID

8 September 2017

author name string

Nada Albarakati

1

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Europe PubMed Central

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8 September 2017

Tarek M A Abdel-Fatah

2

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Europe PubMed Central

PMC publication ID

8 September 2017

Roslin Russell

4

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Europe PubMed Central

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8 September 2017

Christina Perry

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8 September 2017

Arvind Arora

8

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Europe PubMed Central

PMC publication ID

8 September 2017

Nouf Alsubhi

9

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Europe PubMed Central

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8 September 2017

Graham Ball

13

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8 September 2017

publication date

27 August 2014

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8 September 2017

Molecular Oncology

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8 September 2017

9

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8 September 2017

1

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Europe PubMed Central

PMC publication ID

8 September 2017

204-217

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Europe PubMed Central

PMC publication ID

8 September 2017

describes a project that uses

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Europe PubMed Central

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

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Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

1 reference

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Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer

1 reference

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Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy

1 reference

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Interaction between DNA Polymerase β and BRCA1

1 reference

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9 September 2017

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

1 reference

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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

1 reference

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9 September 2017

Mammalian base excision repair: the forgotten archangel

1 reference

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Methylation of BRCA1 promoter region is associated with unfavorable prognosis in women with early-stage breast cancer

1 reference

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PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

1 reference

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The role of BRCA1 in DNA double-strand repair: past and present

1 reference

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Playing the end game: DNA double-strand break repair pathway choice

1 reference

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Mechanisms of BRCA1 tumor suppression

1 reference

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Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models

1 reference

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

1 reference

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Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways

1 reference

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Cytoscape 2.8: new features for data integration and network visualization

1 reference

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The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

1 reference

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BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

1 reference

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9 September 2017

Transcriptional regulation of the base excision repair pathway by BRCA1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528668

9 September 2017

BRCA1 and its toolbox for the maintenance of genome integrity

1 reference

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9 September 2017

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

1 reference

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Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase

1 reference

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9 September 2017

Targeted therapy for cancer using PARP inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528668

9 September 2017

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528668

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Human cancers express a mutator phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528668

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

1 reference

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Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026

1 reference

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9 September 2017

Good timing in the cell cycle for precise DNA repair by BRCA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528668

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

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Hallmarks of 'BRCAness' in sporadic cancers

1 reference

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Diagnosis of multiple cancer types by shrunken centroids of gene expression

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Targeting XRCC1 deficiency in breast cancer for personalized therapy.

1 reference

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9 September 2017

Clinicopathological and functional significance of XRCC1 expression in ovarian cancer

1 reference

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53BP1 promotes ATM activity through direct interactions with the MRN complex

1 reference

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Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.

1 reference

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Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo

1 reference

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ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin

1 reference

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Criteria for analyzing interactions between biologically active agents

1 reference

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BRCA1 up-regulation is associated with repair-mediated resistance to cis-diamminedichloroplatinum(II).

1 reference

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DNA polymerase β deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

1 reference

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25 September 2017

Promoter methylation of BRCA1 in the prognosis of breast cancer: a meta-analysis

1 reference

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21 August 2018

DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.

1 reference

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A validated gene expression profile for detecting clinical outcome in breast cancer using artificial neural networks.

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BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

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Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MOLONC.2014.08.001

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

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