(Q38960209)

English

Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression

scientific article published on 6 September 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression (English)

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

1 reference

based on heuristic

inferred from title

Ignacio I Wistuba

6

object named as

Ignacio I Wistuba

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Europe PubMed Central

8 September 2017

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author name string

Young-Ho Ahn

1

1 reference

Europe PubMed Central

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8 September 2017

Yanan Yang

2

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8 September 2017

Don L Gibbons

3

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Europe PubMed Central

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8 September 2017

Chad J Creighton

4

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Europe PubMed Central

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8 September 2017

Fei Yang

5

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Europe PubMed Central

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8 September 2017

Wei Lin

7

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Nishan Thilaganathan

8

1 reference

Europe PubMed Central

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8 September 2017

Cristina A Alvarez

9

1 reference

Europe PubMed Central

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8 September 2017

Jonathon Roybal

10

1 reference

Europe PubMed Central

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8 September 2017

Elizabeth J Goldsmith

11

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Europe PubMed Central

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8 September 2017

Cathy Tournier

12

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8 September 2017

Jonathan M Kurie

13

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8 September 2017

language of work or name

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publication date

6 September 2011

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Europe PubMed Central

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8 September 2017

Molecular and Cellular Biology

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Europe PubMed Central

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8 September 2017

31

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Europe PubMed Central

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8 September 2017

21

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8 September 2017

4270-4285

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8 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3209326/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer.

1 reference

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9 September 2017

Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors

1 reference

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9 September 2017

A method and server for predicting damaging missense mutations

1 reference

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9 September 2017

TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.

1 reference

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9 September 2017

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch

1 reference

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9 September 2017

HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice

1 reference

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Cancer driver mutations in protein kinase genes

1 reference

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9 September 2017

Design and analysis issues in genome-wide somatic mutation studies of cancer

1 reference

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9 September 2017

c-Jun NH2-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation

1 reference

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9 September 2017

Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations

1 reference

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9 September 2017

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

LKB1 modulates lung cancer differentiation and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

Role of mitogen-activated protein kinase kinase 4 in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

Patterns of somatic mutation in human cancer genomes

1 reference

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9 September 2017

Distinguishing cancer-associated missense mutations from common polymorphisms

1 reference

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9 September 2017

The many faces of PPARgamma

1 reference

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9 September 2017

SIFT: Predicting amino acid changes that affect protein function

1 reference

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9 September 2017

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

Mammalian MAP kinase signalling cascades

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

How MAP kinases are regulated

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

9 September 2017

Loss of MKK4 expression in ovarian cancer: a potential role for the epithelial to mesenchymal transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Signatures of mutation and selection in the cancer genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

K-ras activation generates an inflammatory response in lung tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Somatic mutations of the protein kinase gene family in human lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

14 September 2017

Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

25 September 2017

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

25 September 2017

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

25 September 2017

Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

25 September 2017

Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

17 June 2018

Activators of the nuclear receptor PPARgamma enhance colon polyp formation

1 reference

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17 June 2018

c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209326

21 August 2018

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1 reference

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21 August 2018

A genetic mouse model for metastatic lung cancer with gender differences in survival

1 reference

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12 December 2020

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Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17

1 reference

https://pubmed.ncbi.nlm.nih.gov/21896780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress pathway activation induces phosphorylation of retinoid X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21896780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of Cry1Ab protein mutants of Bacillus thuringiensis by a highly efficient PCR site-directed mutagenesis system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21896780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21896780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21896780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.05562-11

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

release_drmyfljapngehlk3nqxx765vl4

1 reference

https://api.fatcat.wiki/v0/release/drmyfljapngehlk3nqxx765vl4

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

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