(Q38963051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25154814%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability (English)

1 reference

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13 March 2020

1 reference

5

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13 March 2020

author name string

Ahmed Y Ali

1

1 reference

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13 March 2020

Ji-Young Kim

2

1 reference

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13 March 2020

Jean-François Pelletier

3

1 reference

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13 March 2020

Barbara C Vanderhyden

4

1 reference

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13 March 2020

Benjamin K Tsang

6

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13 March 2020

publication date

23 August 2014

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13 March 2020

published in

Molecular Carcinogenesis

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13 March 2020

volume

54

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13 March 2020

issue

11

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13 March 2020

page(s)

1301-1314

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Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt

13 March 2020

cites work

1 reference

Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function

21 January 2018

1 reference

Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells.

21 January 2018

1 reference

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein

21 January 2018

1 reference

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

21 January 2018

1 reference

The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation.

21 January 2018

1 reference

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

21 January 2018

1 reference

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

1 reference

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

21 January 2018

1 reference

The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression

21 January 2018

1 reference

E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.

21 January 2018

1 reference

Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase

21 January 2018

1 reference

Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation

21 January 2018

1 reference

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

21 January 2018

1 reference

The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

21 January 2018

1 reference

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

21 January 2018

1 reference

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

21 January 2018

1 reference

Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

21 January 2018

1 reference

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.

21 January 2018

1 reference

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

1 reference

The Wip1 phosphatase and Mdm2: cracking the "Wip" on p53 stability

21 January 2018

1 reference

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response

21 January 2018

1 reference

Regulation of p53: a collaboration between Mdm2 and Mdmx

21 January 2018

1 reference

PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression

21 January 2018

1 reference

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

1 reference

AKT plays a central role in tumorigenesis

21 January 2018

1 reference

The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

Chemoresistance in human ovarian cancer: the role of apoptotic regulators

21 January 2018

1 reference

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

21 January 2018

1 reference

Wip1 downregulation conserves truncated DNA damage response (DDR) in mitosis

21 January 2018

1 reference

Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53.

21 January 2018

1 reference

Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions

21 January 2018

1 reference

Wip1-dependent signaling pathways in health and diseases

21 January 2018

1 reference

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

21 January 2018

1 reference

Wip1 over-expression correlated with TP53/p14(ARF) pathway disruption in human astrocytomas.

21 January 2018

1 reference

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

1 reference

The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours

21 January 2018

1 reference

Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinoma

21 January 2018

1 reference

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

21 January 2018

1 reference

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

21 January 2018

1 reference

Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner

21 January 2018

1 reference

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

21 January 2018

1 reference

Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer

21 January 2018

1 reference

Orphan nuclear receptor NR4A1 is a negative regulator of DHT-induced rat preantral follicular growth.

21 January 2018

1 reference

Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.

21 January 2018

1 reference

Chemerin suppresses ovarian follicular development and its potential involvement in follicular arrest in rats treated chronically with dihydrotestosterone

21 January 2018

1 reference

RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer.

21 January 2018

1 reference