(Q38990269)

PubMed publication ID

8 September 2017

1 reference

title

Human telomerase reverse transcriptase regulation by DNA methylation, transcription factor binding and alternative splicing (Review) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

alternative mRNA splicing, via spliceosome

13 May 2020

main subject

DNA methylation

0 references

1 reference

3

Martha A Zeiger

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

author name string

Brittany A Avin

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

Christopher B Umbricht

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

publication date

20 October 2016

1 reference

PubMed publication ID

27779655

International Journal of Oncology

8 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

volume

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

page(s)

2199-2205

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

13 May 2020

cites work

1 reference

12 December 2020

A decade of exploring the cancer epigenome - biological and translational implications

1 reference

12 December 2020

Worms gang up on bacteria

1 reference

12 December 2020

Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs

1 reference

12 December 2020

Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation

1 reference

12 December 2020

Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development

1 reference

12 December 2020

Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

1 reference

12 December 2020

Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer

1 reference

12 December 2020

Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.

1 reference

12 December 2020

Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer

1 reference

12 December 2020

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

1 reference

12 December 2020

Expression of human telomerase reverse transcriptase in regenerative and precancerous lesions of cirrhotic livers

1 reference

12 December 2020

Medical genetics and epigenetics of telomerase

1 reference

12 December 2020

CTCF: an architectural protein bridging genome topology and function

1 reference

12 December 2020

WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

1 reference

12 December 2020

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays

1 reference

12 December 2020

CTCF binds the proximal exonic region of hTERT and inhibits its transcription

1 reference

12 December 2020

Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer

1 reference

12 December 2020

Real-time RT-PCR quantification of human telomerase reverse transcriptase splice variants in tumor cell lines and non-small cell lung cancer

1 reference

12 December 2020

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

1 reference

12 December 2020

Eukaryotic DNA methyltransferases--structure and function

1 reference

12 December 2020

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways.

1 reference

12 December 2020

CpG islands and the regulation of transcription

1 reference

12 December 2020

Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene

1 reference

12 December 2020

hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site

1 reference

12 December 2020

Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells

1 reference

12 December 2020

Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients.

1 reference

12 December 2020

Alternative splicing regulation of telomerase: a new paradigm?

1 reference

12 December 2020

HIF-1-mediated activation of telomerase in cervical cancer cells

1 reference

12 December 2020

Regulation of telomerase alternative splicing: a target for chemotherapy

1 reference

12 December 2020

Quantitative relationship between functionally active telomerase and major telomerase components (hTERT and hTR) in acute leukaemia cells

1 reference

12 December 2020

Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

1 reference

12 December 2020

Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells

1 reference

12 December 2020

Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes

1 reference

12 December 2020

Telomerase activity in ductal carcinoma in situ and invasive breast cancer

1 reference

12 December 2020

Chromatin, DNA structure and alternative splicing

1 reference

12 December 2020

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

1 reference

12 December 2020

The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis

1 reference

12 December 2020

Unusual distribution of DNA methylation within the hTERT CpG island in tissues and cell lines

1 reference

12 December 2020

Microenvironmental regulation of telomerase isoforms in human embryonic stem cells

1 reference

12 December 2020

Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer

1 reference

12 December 2020

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

1 reference

12 December 2020

Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers

1 reference

12 December 2020

Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells

1 reference

12 December 2020

Site-specific methylation of CpG nucleotides in the hTERT promoter region can control the expression of hTERT during malignant progression of colorectal carcinoma

1 reference

12 December 2020

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

1 reference

12 December 2020

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

1 reference

12 December 2020

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells

1 reference

12 December 2020

De novo CpG island methylation in human cancer cells

1 reference

12 December 2020

hTERT-based therapy: a universal anticancer approach (Review).

1 reference

12 December 2020

WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo

1 reference

12 December 2020

Oncogene- and drug resistance-associated alternative exon usage in acute myeloid leukemia (AML).

1 reference

12 December 2020

HTERT mRNA partially regulates telomerase activity in gastric adenocarcinoma and adjacent normal gastric mucosa

1 reference

12 December 2020

DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1

1 reference

12 December 2020

Promoter usage and alternative splicing

1 reference

12 December 2020

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

1 reference

12 December 2020

Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index

1 reference

12 December 2020

Telomere length is related to alternative splice patterns of telomerase in thyroid tumors.

1 reference

12 December 2020

WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio

1 reference

12 December 2020

Positive regulation of human telomerase reverse transcriptase gene expression and telomerase activity by DNA methylation in pancreatic cancer.

1 reference

12 December 2020

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

1 reference

12 December 2020

TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116.

1 reference

12 December 2020

Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region

1 reference

12 December 2020

Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant.

1 reference

12 December 2020

Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors

1 reference

12 December 2020

Regulation of alternative splicing through coupling with transcription and chromatin structure

1 reference

12 December 2020

CTCF: from insulators to alternative splicing regulation.

1 reference

12 December 2020

Coupling between transcription and alternative splicing.

1 reference

12 December 2020

WT1 regulates angiogenesis in Ewing Sarcoma

1 reference

12 December 2020

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

1 reference

12 December 2020

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues

1 reference

12 December 2020

Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development

1 reference

12 December 2020

Quantification of alternative splicing variants of human telomerase reverse transcriptase and correlations with telomerase activity in lung cancer

1 reference

12 December 2020

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues

1 reference

12 December 2020

Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres

1 reference

12 December 2020

Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells

1 reference

12 December 2020

Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions.

1 reference

12 December 2020

Exclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptases

1 reference

12 December 2020

Epigenetic regulation of hTERT promoter in hepatocellular carcinomas

1 reference

12 December 2020

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines

1 reference

12 December 2020

The fundamental role of epigenetic events in cancer

1 reference

12 December 2020

Identifiers

DOI

10.3892/IJO.2016.3743

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6903903&resulttype=core&format=json

13 May 2020

PubMed publication ID

27779655

1 reference