(Q39007810)

8 September 2017

title

Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2. (English)

1 reference

amyotrophic lateral sclerosis

8 September 2017

main subject

Drosophila melanogaster

0 references

0 references

Amyotrophic lateral sclerosis 2 Dmel_CG7158

1 reference

GOA release 2020-03-11

author

Reina E Itoh

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Tadashi Uemura

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Yuta Takayama

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Taiichi Tsuyama

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

7 April 2014

1 reference

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

464-477

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

13 June 2020

cites work

1 reference

Hereditary motor system diseases (chronic juvenile amyotrophic lateral sclerosis). Conditions combining a bilateral pyramidal syndrome with limb and bulbar amyotrophy

21 January 2018

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Onset and progression in inherited ALS determined by motor neurons and microglia

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Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

21 January 2018

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ALS2/alsin knockout mice and motor neuron diseases

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Systematic discovery of Rab GTPases with synaptic functions in Drosophila

21 January 2018

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Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila

21 January 2018

1 reference

Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

21 January 2018

1 reference

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

21 January 2018

1 reference

Gradient formation of the TGF-beta homolog Dpp.

21 January 2018

1 reference

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

21 January 2018

1 reference

On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster

21 January 2018

1 reference

The NCBI BioSystems database

21 January 2018

1 reference

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

21 January 2018

1 reference

Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.

21 January 2018

1 reference

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

21 January 2018

1 reference

Selective expression of Knot/Collier, a transcriptional regulator of the EBF/Olf-1 family, endows the Drosophila sensory system with neuronal class-specific elaborated dendritic patterns.

21 January 2018

1 reference

The adult abdominal neuromuscular junction of Drosophila: a model for synaptic plasticity.

21 January 2018

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Probing mechanisms that underlie human neurodegenerative diseases in Drosophila

21 January 2018

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Branching out: mechanisms of dendritic arborization

21 January 2018

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A GAL4-driver line resource for Drosophila neurobiology

21 January 2018

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Conversion of plasma membrane topology during epithelial tube connection requires Arf-like 3 small GTPase in Drosophila

21 January 2018

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Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences

21 January 2018

1 reference

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

21 January 2018

1 reference

Development of larval motor circuits in Drosophila

21 January 2018

1 reference

Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking

21 January 2018

1 reference

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

21 January 2018

1 reference

Hypergravity and Aging in <i>Drosophila melanogaster. </i>4. Climbing Activity

21 January 2018

1 reference

Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants

21 January 2018

1 reference

The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain

21 January 2018

1 reference

The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons.

21 January 2018

1 reference

Development and plasticity of the Drosophila larval neuromuscular junction

21 January 2018

1 reference

Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons

21 January 2018

1 reference

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

21 January 2018

1 reference

Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

21 January 2018

1 reference

The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons

21 January 2018

1 reference

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

21 January 2018

1 reference

Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila

21 January 2018

1 reference

The Pfam protein families database

21 January 2018

1 reference

The changing scene of amyotrophic lateral sclerosis

21 January 2018

1 reference

Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans

21 January 2018

1 reference

Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes

21 January 2018

1 reference

Multidendritic sensory neurons in the adult Drosophila abdomen: origins, dendritic morphology, and segment- and age-dependent programmed cell death

21 January 2018

1 reference

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

21 January 2018

1 reference

FlyBase 102--advanced approaches to interrogating FlyBase

21 January 2018

1 reference

Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process

21 January 2018

1 reference

In vivo fluorescent adenosine 5'-triphosphate (ATP) imaging of Drosophila melanogaster and Caenorhabditis elegans by using a genetically encoded fluorescent ATP biosensor optimized for low temperatures.

21 January 2018

1 reference

A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.

21 January 2018

1 reference

The molecular and cellular basis of bitter taste in Drosophila.

21 January 2018

1 reference

Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

21 January 2018

1 reference

Control of axonal sprouting and dendrite branching by the Nrg-Ank complex at the neuron-glia interface

21 January 2018

1 reference

Progressive spinal axonal degeneration and slowness in ALS2-deficient mice

21 January 2018

1 reference

Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

21 January 2018

1 reference

Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila

21 January 2018

1 reference

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

21 January 2018

1 reference

Distal axonopathy in an alsin-deficient mouse model

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/GTC.12146

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24702731%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference