(Q57372624)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17409386%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

title

The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis (English)

1 reference

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28 December 2019

2

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28 December 2019

author name string

Ryota Kunita

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17409386%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Hikaru Mizumura

3

1 reference

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28 December 2019

Kyoko Suzuki-Utsunomiya

4

1 reference

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28 December 2019

Shinji Hadano

5

1 reference

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28 December 2019

Joh-E Ikeda

6

1 reference

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28 December 2019

language of work or name

English

0 references

publication date

4 April 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17409386%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

28 December 2019

number of pages

13

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

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28 December 2019

volume

282

1 reference

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28 December 2019

issue

22

1 reference

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28 December 2019

page(s)

16599-16611

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17409386%20AND%20SRC:MED&resulttype=core&format=json

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

28 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Junctophilins: a novel family of junctional membrane complex proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The N-terminal membrane occupation and recognition nexus domain of Arabidopsis phosphatidylinositol phosphate kinase 1 regulates enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Alsin/Rac1 signaling controls survival and growth of spinal motoneurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Rab proteins as membrane organizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Targeting Rab GTPases to distinct membrane compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The Rab5 effector EEA1 is a core component of endosome docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Association of early endosomal autoantigen 1 with macropinocytosis in EGF-stimulated A431 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Regulation of receptor-mediated endocytosis by Rho and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Rin1 regulates insulin receptor signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Endocytosis and molecular sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Erratum to “Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers” [Biochim. Biophys. Acta 1744 (2005) 273–286]

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Caveolin-Stabilized Membrane Domains as Multifunctional Transport and Sorting Devices in Endocytic Membrane Traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Progressive spinal axonal degeneration and slowness in ALS2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610682200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610682200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17409386%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference