(Q39009607)

English

Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.

scientific article published on 21 May 2014

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12 March 2020

Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status (English)

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12 March 2020

Philip J. Coates

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12 March 2020

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12 March 2020

Philip R Quinlan

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12 March 2020

Bořivoj Vojtěšek

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Borivoj Vojtesek

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12 March 2020

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Pavla Bouchalova

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12 March 2020

Rudolf Nenutil

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12 March 2020

Roman Hrstka

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12 March 2020

M Virginia Appleyard

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12 March 2020

Karen Murray

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12 March 2020

Lee B Jordan

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12 March 2020

Alastair M Thompson

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12 March 2020

publication date

21 May 2014

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12 March 2020

Journal of Pathology

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12 March 2020

233

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12 March 2020

3

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12 March 2020

238-246

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12 March 2020

Shaping genetic alterations in human cancer: the p53 mutation paradigm

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Tumor suppressive functions of p53

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

The role of mutant p53 in human cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Clinical outcomes and correlates of TP53 mutations and cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

P53 in tumour pathology: can we trust immunocytochemistry?

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

p53 allele losses, mutations and expression in breast cancer and their relationship to clinico-pathological parameters

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Ubiquitination and degradation of mutant p53.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Chaperone-dependent stabilization and degradation of p53 mutants

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Investigation and prediction of the severity of p53 mutants using parameters from structural calculations

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Multiple stress signals activate mutant p53 in vivo

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Detection of the p53 response in zebrafish embryos using new monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

p53 mutation, deprivation and poor prognosis in primary breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Differential contextual responses of normal human breast epithelium to ionizing radiation in a mouse xenograft model

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Increased mortality in HER2 positive, oestrogen receptor positive invasive breast cancer: a population-based study

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

HER2 assessment on core biopsy specimens using monoclonal antibody CB11 accurately determines HER2 status in breast carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Distinct p53 gene signatures are needed to predict prognosis and response to chemotherapy in ER-positive and ER-negative breast cancers

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

Does control of mutant p53 by Mdm2 complicate cancer therapy?

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4356

21 January 2018

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