(Q40478075)

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Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

author name string

Pavla Ceskova

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Borek Vojtesek

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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21 December 2004

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Journal of Biological Chemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

280

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

6682-6691

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15613472%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Presence of a potent transcription activating sequence in the p53 protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Refined solution structure of the oligomerization domain of the tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Regulation of the specific DNA binding function of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Allosteric activation of latent p53 tetramers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Cancer. p53, guardian of the genome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

New approaches to understanding p53 gene tumor mutation spectra

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Rescuing the function of mutant p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Phosphorylation and hsp90 binding mediate heat shock stabilization of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Therapeutic and diagnostic implications of Hsp90 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Hsp90: an emerging target for breast cancer therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Mapping of the p53 and mdm-2 interaction domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Screening the p53 status of human cell lines using a yeast functional assay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

The role of p53 in chemosensitivity and radiosensitivity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Hsp90 chaperones wild-type p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Hsp90: a specialized but essential protein-folding tool

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Insights into the function of Hsp70 chaperones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Heat-shock protein 90, a chaperone for folding and regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Structure and functional relationships of Hsp90.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

Rho-modifying C3-like ADP-ribosyltransferases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412767200

21 January 2018

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