(Q39013925)

8 September 2017

A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity (English)

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8 September 2017

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Masaaki Matsuoka

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8 September 2017

Yuichi Hashimoto

1

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PubMed ID

24646423

8 September 2017

language of work or name

English

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publication date

10 April 2014

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Journal of Neurochemistry

8 September 2017

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8 September 2017

130

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8 September 2017

2

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8 September 2017

291-300

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Amyloid precursor protein mediates a tyrosine kinase-dependent activation response in endothelial cells

8 September 2017

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The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

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Cdk5 deregulation in the pathogenesis of Alzheimer's disease

21 January 2018

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A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

21 January 2018

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Altered expression of transforming growth factor-beta in Alzheimer's disease.

21 January 2018

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Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

21 January 2018

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Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

21 January 2018

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Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.

21 January 2018

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The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

21 January 2018

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Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein

21 January 2018

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Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta.

21 January 2018

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Assembly and activation of the γ-secretase complex: roles of presenilin cofactors

21 January 2018

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

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Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein-relevant insults

21 January 2018

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

21 January 2018

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

21 January 2018

1 reference

Humanin; a defender against Alzheimer's disease?

21 January 2018

1 reference

Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis

21 January 2018

1 reference

Calcium and neurodegeneration

21 January 2018

1 reference

Alzheimer's disease sends the wrong signals--a perspective

21 January 2018

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Death and survival of neuronal cells exposed to Alzheimer's insults

21 January 2018

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Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons

21 January 2018

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Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains.

21 January 2018

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Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells

21 January 2018

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Can the calcium hypothesis explain synaptic loss in Alzheimer's disease?

21 January 2018

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A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

21 January 2018

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Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein

21 January 2018

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Secreted Abeta does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein

21 January 2018

1 reference

MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins

21 January 2018

1 reference

Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations.

21 January 2018

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SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase

21 January 2018

1 reference

Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies

21 January 2018

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Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

1 reference

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

21 January 2018

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

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Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

21 January 2018

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JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.12717

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8 September 2017

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PubMed ID

24646423