(Q39024579)

8 September 2017

1 reference

13 November 2020

The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target (English)

1 reference

complement system proteins

8 September 2017

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27 September 2019

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13 November 2020

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14 October 2020

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13 November 2020

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PubMed publication ID

27902638

author

Ursula Schmidt-Erfurth

2

object named as

Ursula Schmidt-Erfurth

1 reference

8 September 2017

David S Boyer

1

1 reference

8 September 2017

Menno van Lookeren Campagne

3

1 reference

8 September 2017

Erin C Henry

4

1 reference

8 September 2017

Christopher Brittain

5

1 reference

8 September 2017

language of work or name

1 reference

29 November 2016

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8 September 2017

1 May 2017

7 references

25 April 2019

25 June 2019

27 September 2019

27 November 2019

13 December 2019

14 October 2020

13 November 2020

8 references

8 September 2017

25 April 2019

25 June 2019

27 September 2019

27 November 2019

13 December 2019

14 October 2020

13 November 2020

37

1 reference

8 September 2017

5

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8 September 2017

819-835

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Creative Commons Attribution-NonCommercial-NoDerivatives

8 September 2017

7 references

25 April 2019

25 June 2019

27 September 2019

27 November 2019

13 December 2019

14 October 2020

13 November 2020

on focus list of Wikimedia project

ScienceSource

0 references

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Comparison of Geographic Atrophy Growth Rates Using Different Imaging Modalities in the COMPLETE Study

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Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

9 September 2017

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DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration

9 September 2017

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Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.

9 September 2017

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Genetic variants in the complement system predisposing to age-related macular degeneration: a review

9 September 2017

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Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration

9 September 2017

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How many people in England and Wales are registered partially sighted or blind because of age-related macular degeneration?

9 September 2017

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IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration

9 September 2017

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The role of complement dysregulation in AMD mouse models.

9 September 2017

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Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release

9 September 2017

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Diagnostic sensitivity and specificity of dark adaptometry for detection of age-related macular degeneration.

9 September 2017

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Predictors for the progression of geographic atrophy in patients with age-related macular degeneration: fundus autofluorescence study with modified fundus camera

9 September 2017

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Geographic atrophy: clinical features and potential therapeutic approaches

9 September 2017

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Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study

9 September 2017

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Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes with nonneovascular age-related macular degeneration.

9 September 2017

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Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration.

9 September 2017

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Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration

9 September 2017

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Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

9 September 2017

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Update on current and future novel therapies for dry age-related macular degeneration

9 September 2017

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Aging is not a disease: distinguishing age-related macular degeneration from aging

9 September 2017

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Stem cell-based treatment in geographic atrophy: promises and pitfalls

9 September 2017

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Optical coherence tomography-based observation of the natural history of drusenoid lesion in eyes with dry age-related macular degeneration

9 September 2017

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Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury

9 September 2017

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Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.

9 September 2017

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Immunology of age-related macular degeneration

9 September 2017

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Reticular macular disease is associated with multilobular geographic atrophy in age-related macular degeneration

9 September 2017

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Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration

9 September 2017

1 reference

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Seven new loci associated with age-related macular degeneration

9 September 2017

1 reference

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Clinical classification of age-related macular degeneration

9 September 2017

1 reference

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Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

9 September 2017

1 reference

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The complement system: an unexpected role in synaptic pruning during development and disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Does complement play a role in bone development and regeneration?

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

9 September 2017

1 reference

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Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: a meta-analysis

9 September 2017

1 reference

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A rare penetrant mutation in CFH confers high risk of age-related macular degeneration.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor D in age-related macular degeneration

9 September 2017

1 reference

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Imaging geographic atrophy in age-related macular degeneration

9 September 2017

1 reference

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Elevated membrane attack complex in human choroid with high risk complement factor H genotypes

9 September 2017

1 reference

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Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A systematic comparison of spectral-domain optical coherence tomography and fundus autofluorescence in patients with geographic atrophy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Changes in retinal sensitivity in geographic atrophy progression as measured by microperimetry

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement: a key system for immune surveillance and homeostasis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Foveal-Sparing Scotomas in Advanced Dry Age-Related Macular Degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Therapeutic potential of complement modulation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement regulators and inhibitory proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement activation by bisretinoid constituents of RPE lipofuscin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Night vision symptoms and progression of age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

The epidemiology of progression of pure geographic atrophy: the Beaver Dam Eye Study

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Systemic complement activation in age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Low luminance visual dysfunction as a predictor of subsequent visual acuity loss from geographic atrophy in age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Oxidative damage-induced inflammation initiates age-related macular degeneration.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

The classical complement cascade mediates CNS synapse elimination

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Structural basis for complement factor H linked age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor H and the hemolytic uremic syndrome

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trials

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Long-term follow-up of fixation patterns in eyes with central scotomas from geographic atrophy that is associated with age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor H polymorphism in age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor H polymorphism and age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor H variant increases the risk of age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Prevalence of age-related macular degeneration in the United States

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Symmetry of bilateral lesions in geographic atrophy in patients with age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Delays in rod-mediated dark adaptation in early age-related maculopathy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement. Second of two parts

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement. First of two parts

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: Age-Related Eye Disease Study Report Number 3

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

The internal thioester and the covalent binding properties of the complement proteins C3 and C4

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement factor D, a novel serine protease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Mechanism of action of factor D of the alternative complement pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Optical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degeneration.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Topography of geographic atrophy in age-related macular degeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

The influence of C3b inactivator (KAF) concentration on the ability of serum to support complement activation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Progression of age-related geographic atrophy: role of the fellow eye.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Population Pharmacokinetics and Pharmacodynamics of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Concordance of disease progression in bilateral geographic atrophy due to AMD.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Lipofuscin of the retinal pigment epithelium: a review

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

IL-18 is not therapeutic for neovascular age-related macular degeneration

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A longitudinal comparison of spectral-domain optical coherence tomography and fundus autofluorescence in geographic atrophy.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A systematic correlation of morphology and function using spectral domain optical coherence tomography and microperimetry in patients with geographic atrophy.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Understanding RPE lipofuscin

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A phase ia dose-escalation study of the anti-factor D monoclonal antibody fragment FCFD4514S in patients with geographic atrophy

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A functional variant in the CFI gene confers a high risk of age-related macular degeneration

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

The amplification loop of the complement pathways.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A potential role for immune complex pathogenesis in drusen formation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424580

Low-Luminance Visual Acuity and Microperimetry in Age-Related Macular Degeneration

2 December 2018

1 reference

12 December 2020

Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration

1 reference

12 December 2020

Square root transformation of geographic atrophy area measurements to eliminate dependence of growth rates on baseline lesion measurements: a reanalysis of age-related eye disease study report no. 26

1 reference

12 December 2020

Evolution of geographic atrophy of the retinal pigment epithelium

1 reference

12 December 2020

A rare variant in CFH directly links age-related macular degeneration with rare glomerular nephropathies

1 reference

12 December 2020

Risk Alleles in CFH and ARMS2 Are Independently Associated with Systemic Complement Activation in Age-related Macular Degeneration

1 reference

12 December 2020

The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation

1 reference

12 December 2020

Fifteen-Year Cumulative Incidence of Age-Related Macular Degeneration

1 reference

12 December 2020

The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification

1 reference

12 December 2020

Impaired mesopic visual acuity in eyes with early age-related macular degeneration

1 reference

12 December 2020

Cone- and rod-mediated dark adaptation impairment in age-related maculopathy

1 reference

12 December 2020

10.1097/IAE.0000000000001392

Identifiers

DOI

1 reference

8 September 2017

1 reference

8 September 2017

PubMed publication ID

27902638

1 reference