(Q39025697)

8 September 2017

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title

Mitochondrial purine and pyrimidine metabolism and beyond (English)

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8 September 2017

Liya Wang

1

1 reference

8 September 2017

publication date

1 December 2016

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Nucleosides, Nucleotides & Nucleic Acids

8 September 2017

published in

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8 September 2017

volume

35

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8 September 2017

issue

10-12

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8 September 2017

page(s)

578-594

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DNA building blocks: keeping control of manufacture

8 September 2017

cites work

1 reference

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Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells

21 January 2018

1 reference

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Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion

21 January 2018

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The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.

21 January 2018

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Structure and function of cellular deoxyribonucleoside kinases

21 January 2018

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Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters

21 January 2018

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Mitochondrial transporters of the SLC25 family and associated diseases: a review

21 January 2018

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The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress

21 January 2018

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Mitochondrial and submitochondrial localization of human deoxyguanosine kinase

21 January 2018

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The intracellular localization of deoxycytidine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Intracellular location of thymidylate synthase and its state of phosphorylation

21 January 2018

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Ribonucleotide reductase: evidence for specific association with HeLa cell mitochondria.

21 January 2018

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Ribonucleotide reductase association with mammalian liver mitochondria

21 January 2018

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Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

21 January 2018

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Heart mitochondrial TTP synthesis and the compartmentalization of TMP.

21 January 2018

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Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances

21 January 2018

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S-glutathionylation in protein redox regulation.

21 January 2018

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Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Oxidative stress induced S-glutathionylation and proteolytic degradation of mitochondrial thymidine kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

The mitochondrial DNA polymerase as a target of oxidative damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Thioredoxin is required for deoxyribonucleotide pool maintenance during S phase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs

21 January 2018

1 reference

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The mitochondrial ADP/ATP carrier (SLC25 family): pathological implications of its dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Functional dissection of the N-terminal degron of human thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

dNTP pools determine fork progression and origin usage under replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Telomere length homeostasis responds to changes in intracellular dNTP pools

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Altered thymidine metabolism due to defects of thymidine phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial myopathy and cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Disruption of the mevalonate pathway induces dNTP depletion and DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Polymerase gamma mutator mice rely on increased glycolytic flux for energy production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Metabolic pathways promoting cancer cell survival and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Global genetic determinants of mitochondrial DNA copy number

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

Mitochondria as determinant of nucleotide pools and chromosomal stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2015.1125001

10.1080/15257770.2015.1125001

21 January 2018

Identifiers

DOI

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8 September 2017

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