(Q39065925)

8 September 2017

Macrocycles: lessons from the distant past, recent developments, and future directions (English)

1 reference

8 September 2017

Andrei K Yudin

1

1 reference

PMCID

5424464

8 September 2017

language of work or name

1 reference

3 November 2014

1 reference

8 September 2017

1 reference

8 September 2017

6

1 reference

8 September 2017

1

1 reference

8 September 2017

30-49

1 reference

How proteins bind macrocycles.

8 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Controlling biological activity with light: diarylethene-containing cyclic peptidomimetics

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

mRNA display: from basic principles to macrocycle drug discovery

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

The future of peptide-based drugs

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

N-methylation of peptides and proteins: an important element for modulating biological functions

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Intestinal permeability of cyclic peptides: common key backbone motifs identified.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Stapled peptides for intracellular drug targets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Strained cyclophane macrocycles: impact of progressive ring size reduction on synthesis and structure

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Assessing helical protein interfaces for inhibitor design

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Contemporary strategies for peptide macrocyclization

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Coexistence of passive and carrier-mediated processes in drug transport

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Update 1 of: Proteases universally recognize beta strands in their active sites

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Beta-hairpin peptidomimetics: design, structures and biological activities

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Ribosomal synthesis of peptidase-resistant peptides closed by a nonreducible inter-side-chain bond

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Cyclic modular beta-sheets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Readily Available Unprotected Amino Aldehydes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Mammalian defensins in the antimicrobial immune response

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

What can a chemist learn from nature's macrocycles?--a brief, conceptual view.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

The N-terminal to C-terminal motif in protein folding and function

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Keeping dry and crossing membranes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

DNA-templated organic synthesis and selection of a library of macrocycles

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Conformationally homogeneous cyclic tetrapeptides: useful new three-dimensional scaffolds

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Biomimetic synthesis and optimization of cyclic peptide antibiotics

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

The green fluorescent protein

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Unusual beta-sheet periodicity in small cyclic peptides

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Cyclosporin metabolism in transplant patients

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Electronic tuning of site-selectivity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Total synthesis of palau'amine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Design of peptides, proteins, and peptidomimetics in chi space.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Enteral absorption of octreotide: absorption enhancement by polyoxyethylene-24-cholesterol ether

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Stereoselective fluorination alters the geometry of a cyclic peptide: exploration of backbone-fluorinated analogues of unguisin A.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Exocyclic control of turn induction in macrocyclic peptide scaffolds.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Zwitterionic ring-opening polymerization for the synthesis of high molecular weight cyclic polymers

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Phase separation as a strategy toward controlling dilution effects in macrocyclic Glaser-Hay couplings.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Cyclative cleavage through dipolar cycloaddition: polymer-bound azidopeptidylphosphoranes deliver locked cis-triazolylcyclopeptides as privileged protein binders.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Conformational analysis of macrocycles: finding what common search methods miss.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

An unusual reverse turn structure adopted by a furanoid sugar amino acid incorporated in gramicidin S.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Antibacterial agents based on the cyclic D,L-alpha-peptide architecture

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5424464

Hydrogen-bond driven loop-closure kinetics in unfolded polypeptide chains

21 August 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

The Structure of Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

Ring size configuration effect and the transannular intrinsic rates in bislactam macrocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

A Cyclic β-Strand Tripeptide with an α-Helix Like CD Spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

Site-Selective Derivatization and Remodeling of Erythromycin A by Using Simple Peptide-Based Chiral Catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

Conformationally Constrained Cyclic Peptides: Powerful Scaffolds for Asymmetric Catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

N-Heterocyclic Carbene-Mediated Zwitterionic Polymerization of N-Substituted N-Carboxyanhydrides toward Poly(α-peptoid)s: Kinetic, Mechanism, and Architectural Control

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC03089C

Conformational constraint in protein ligand design and the inconsistency of binding entropy

21 January 2018

1 reference

12 December 2020

Natural macrocyclic molecules have a possible limited structural diversity

1 reference

12 December 2020

Ion Pair Driven Self-Assembly of a Flexible Bis-Zwitterion in Polar Solution: Formation of Discrete Nanometer-Sized Cyclic Dimers

1 reference

12 December 2020

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

1 reference

12 December 2020

Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions

1 reference

12 December 2020

Site-specific integration of amino acid fragments into cyclic peptides

1 reference

12 December 2020

Asymmetric catalysis of the transannular Diels-Alder reaction

1 reference

12 December 2020

Macrocyclization of linear peptides enabled by amphoteric molecules

1 reference

12 December 2020

Efficient parallel synthesis of macrocyclic peptidomimetics

1 reference

12 December 2020

A new and useful method for the macrocyclization of linear peptides

1 reference

12 December 2020

Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces

1 reference

12 December 2020

Identifiers

DOI

10.1039/C4SC03089C

1 reference

8 September 2017

1 reference

8 September 2017

1 reference

PMCID

5424464