(Q39082252)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51 (English)

1 reference

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9 April 2020

2

1 reference

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9 April 2020

Hervé Técher

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Giorgio Baldi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Vincenzo Costanzo

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

author name string

Arun Mouli Kolinjivadi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Anna de Antoni

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

language of work or name

English

0 references

publication date

30 January 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

volume

591

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

page(s)

1083-1100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

Mechanisms of replication fork protection: a safeguard for genome stability

9 April 2020

cites work

1 reference

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Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

21 January 2018

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Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns

21 January 2018

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Molecular views of recombination proteins and their control

21 January 2018

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Homologous repair of DNA damage and tumorigenesis: the BRCA connection

21 January 2018

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Mechanism of eukaryotic homologous recombination

21 January 2018

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Multiplicity of DNA end resection machineries in chromosome break repair

21 January 2018

1 reference

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Human CtIP promotes DNA end resection

21 January 2018

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Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection.

21 January 2018

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Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

21 January 2018

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DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

21 January 2018

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Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

21 January 2018

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Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

21 January 2018

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Non-homologous end joining: emerging themes and unanswered questions

21 January 2018

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Mechanism and regulation of DNA end resection in eukaryotes

21 January 2018

1 reference

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Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway

21 January 2018

1 reference

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Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities

21 January 2018

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Reconstitution of recombination-associated DNA synthesis with human proteins.

21 January 2018

1 reference

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Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

21 January 2018

1 reference

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Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Stimulation by Rad52 of yeast Rad51-mediated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

21 January 2018

1 reference

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Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA

21 January 2018

1 reference

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Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Purified human BRCA2 stimulates RAD51-mediated recombination

21 January 2018

1 reference

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Rescuing stalled or damaged replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Replisome-mediated translesion synthesis and leading strand template lesion skipping are competing bypass mechanisms

21 January 2018

1 reference

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When replication travels on damaged templates: bumps and blocks in the road

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

DNA damage-induced replication fork regression and processing in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

RecA-Dependent Recovery of Arrested DNA Replication Forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

The active form of DNA polymerase V is UmuD'(2)C-RecA-ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

The Escherichia coli replisome is inherently DNA damage tolerant

21 January 2018

1 reference

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Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switch

21 January 2018

1 reference

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Studying essential DNA metabolism proteins in Xenopus egg extract

21 January 2018

1 reference

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Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

21 January 2018

1 reference

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Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

21 January 2018

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Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

21 January 2018

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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

21 January 2018

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RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

21 January 2018

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Break-induced replication and telomerase-independent telomere maintenance require Pol32.

21 January 2018

1 reference

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POLD3 Is Haploinsufficient for DNA Replication in Mice.

21 January 2018

1 reference

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Rad52 forms DNA repair and recombination centers during S phase

21 January 2018

1 reference

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Break-induced telomere synthesis underlies alternative telomere maintenance

21 January 2018

1 reference

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Replication stress activates DNA repair synthesis in mitosis.

21 January 2018

1 reference

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Replication fork reversal and the maintenance of genome stability

21 January 2018

1 reference

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Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

21 January 2018

1 reference

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Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

21 January 2018

1 reference

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Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the Polα/Primase/Ctf4 Complex

21 January 2018

1 reference

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Mta2 promotes Tipin-dependent maintenance of replication fork integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Cooperation of RAD51 and RAD54 in regression of a model replication fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Replication fork reversal in eukaryotes: from dead end to dynamic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

The MRN complex in double-strand break repair and telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

21 January 2018

1 reference

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Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

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Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Replication stress: getting back on track

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

21 January 2018

1 reference

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A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

21 January 2018

1 reference

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Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

RIF1 counteracts BRCA1-mediated end resection during DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

53BP1 regulates DSB repair using Rif1 to control 5' end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Replication fork stability confers chemoresistance in BRCA-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Maintaining genome stability at the replication fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Priming for tolerance and cohesion at replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Linking DNA polymerase theta structure and function in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Mutational processes molding the genomes of 21 breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Signatures of mutational processes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Deciphering signatures of mutational processes operative in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Mechanism of replication-coupled DNA interstrand crosslink repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12556

21 January 2018

Identifiers

DOI

10.1002/1873-3468.12556

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28079255%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference