(Q39095156)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28103219%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

The pharmacological regulation of cellular mitophagy (English)

1 reference

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9 April 2020

1 reference

2

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9 April 2020

author name string

Nikolaos D Georgakopoulos

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28103219%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Michelangelo Campanella

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28103219%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

publication date

1 January 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28103219%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

published in

Nature Chemical Biology

1 reference

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9 April 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28103219%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28103219%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

page(s)

136-146

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https://scigraph.springernature.com/pub.10.1038/nchembio.2287

9 April 2020

exact match

0 references

cites work

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Mitophagy mechanisms and role in human diseases

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Ubiquitin-Dependent And Independent Signals In Selective Autophagy

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 January 2018

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

21 January 2018

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

21 January 2018

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Image-based genome-wide siRNA screen identifies selective autophagy factors

21 January 2018

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Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

21 January 2018

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Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

21 January 2018

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Nix is a selective autophagy receptor for mitochondrial clearance

21 January 2018

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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

21 January 2018

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Essential role for Nix in autophagic maturation of erythroid cells

21 January 2018

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The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway

21 January 2018

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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

21 January 2018

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Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

21 January 2018

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Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.

21 January 2018

1 reference

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A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells

21 January 2018

1 reference

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Opening of cardiac sarcolemmal KATP channels by dinitrophenol separate from metabolic inhibition

21 January 2018

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Differential mitochondrial toxicity screening and multi-parametric data analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

The pathways of mitophagy for quality control and clearance of mitochondria

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Early effects of the antineoplastic agent salinomycin on mitochondrial function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

A critical role of superoxide anion in selenite-induced mitophagic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro

21 January 2018

1 reference

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Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

21 January 2018

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Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

21 January 2018

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Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

21 January 2018

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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

21 January 2018

1 reference

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Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

21 January 2018

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Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

21 January 2018

1 reference

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21 January 2018

Mechanisms of mitophagy

1 reference

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A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.

21 January 2018

1 reference

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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

21 January 2018

1 reference

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Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mechanism and function of deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Loss of iron triggers PINK1/Parkin-independent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mitochondrial fragmentation caused by phenanthroline promotes mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

New method to assess mitophagy flux by flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Nicotinamide enhances mitochondria quality through autophagy activation in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Deacetylation of nuclear LC3 drives autophagy initiation under starvation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

The emerging role of Nrf2 in mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

PMI: a ΔΨm independent pharmacological regulator of mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Sulforaphane induces autophagy through ERK activation in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Application and interpretation of current autophagy inhibitors and activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mitochondrial division/mitophagy inhibitor (Mdivi) ameliorates pressure overload induced heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Rheb regulates mitophagy induced by mitochondrial energetic status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

7 January 2021

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

7 January 2021

The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

7 January 2021

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

7 January 2021

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2287

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28103219%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference