(Q39385204)

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The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

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scholarly article

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Europe PubMed Central

11 September 2017

The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer (English)

1 reference

Europe PubMed Central

11 September 2017

6

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B M Evers

1 reference

Europe PubMed Central

11 September 2017

author name string

X Li

1

1 reference

Europe PubMed Central

11 September 2017

P D Stevens

2

1 reference

Europe PubMed Central

11 September 2017

H Yang

3

1 reference

Europe PubMed Central

11 September 2017

P Gulhati

4

1 reference

Europe PubMed Central

11 September 2017

W Wang

5

1 reference

Europe PubMed Central

11 September 2017

T Gao

7

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Europe PubMed Central

11 September 2017

language of work or name

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publication date

5 March 2012

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Europe PubMed Central

11 September 2017

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Europe PubMed Central

11 September 2017

32

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Europe PubMed Central

11 September 2017

4

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Europe PubMed Central

11 September 2017

471-478

1 reference

Europe PubMed Central

11 September 2017

https://scigraph.springernature.com/pub.10.1038/onc.2012.66

0 references

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

SCOP/PHLPP and its functional role in the brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Breaking the chains: structure and function of the deubiquitinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Defining the human deubiquitinating enzyme interaction landscape

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

PHLiPPing the switch on Akt and protein kinase C signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

The phosphatase PHLPP controls the cellular levels of protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

The ubiquitin-specific protease USP28 is required for MYC stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

11 September 2017

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

14 September 2017

beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

14 September 2017

Skp2 regulates Myc protein stability and activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371166

14 September 2017

Immunocytochemical localization of estrogen and progesterone receptor and prognosis in human primary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22391563

12 December 2020

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10.1038/ONC.2012.66

1 reference

Europe PubMed Central

11 September 2017

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1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

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