(Q39449351)

12 September 2017

title

Cdc20 control of cell fate during prolonged mitotic arrest: do Cdc20 protein levels affect cell fate in response to antimitotic compounds? (English)

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12 September 2017

Jakob Nilsson

1

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language of work or name

English

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publication date

2 November 2011

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12 September 2017

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12 September 2017

volume

33

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12 September 2017

issue

12

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12 September 2017

page(s)

903-909

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The spindle-assembly checkpoint in space and time

12 September 2017

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UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

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The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

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Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

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Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

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Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1.

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Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

21 January 2018

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APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

21 January 2018

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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

21 January 2018

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Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

21 January 2018

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Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae

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21 January 2018

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21 January 2018

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21 January 2018

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Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

21 January 2018

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21 January 2018

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21 January 2018

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Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate

21 January 2018

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Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.

21 January 2018

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Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

21 January 2018

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Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.

21 January 2018

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21 January 2018

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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201100094

Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201100094

Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer

21 January 2018

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Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

21 January 2018

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Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201100094

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201100094

Cell division: aurora B illuminates a checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100094

The spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100094

No Way Out for Tumor Cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201100094

21 January 2018

Identifiers

DOI

10.1002/BIES.201100094

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release_xfh7smqmzvho3kim5a3rex5iue

12 September 2017

Fatcat ID

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