(Q39456845)

12 September 2017

Endoplasmic Reticulum Stress and the Hallmarks of Cancer (English)

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12 September 2017

endoplasmic reticulum

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author name string

Hery Urra

1

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12 September 2017

Estefanie Dufey

2

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12 September 2017

Tony Avril

3

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12 September 2017

Eric Chevet

4

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12 September 2017

Claudio Hetz

5

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12 September 2017

23 April 2016

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12 September 2017

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12 September 2017

2

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12 September 2017

5

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12 September 2017

252-262

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Hallmarks of Cancer: The Next Generation

12 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The role of the unfolded protein response in tumour development: friend or foe?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Translational control in cancer etiology

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Addicted to secrete - novel concepts and targets in cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Endoplasmic reticulum stress in malignancy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

GRP78 induction in cancer: therapeutic and prognostic implications.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

ER proteostasis addiction in cancer biology: Novel concepts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Proteostasis control by the unfolded protein response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Targeting the unfolded protein response in disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded protein response: from stress pathway to homeostatic regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Getting RIDD of RNA: IRE1 in cell fate regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

When ER stress reaches a dead end

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Tumor progression and the different faces of the PERK kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Patterns of somatic mutation in human cancer genomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The role of X-box binding protein-1 in tumorigenicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Molecular regulation of vessel maturation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

ER Stress and Angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

A novel ER stress-independent function of the UPR in angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8⁺ T cell priming

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Control of systemic proteostasis by the nervous system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Models, mechanisms and clinical evidence for cancer dormancy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Cancer dormancy: a model of early dissemination and late cancer recurrence.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Multiple Gene Expression Classifiers from Different Array Platforms Predict Poor Prognosis of Colorectal Cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Multiclass cancer diagnosis using tumor gene expression signatures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

PERK mediates cell-cycle exit during the mammalian unfolded protein response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded protein response is not necessary for the G1/S transition, but it is required for chromosome maintenance in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

ATM blocks tunicamycin-induced endoplasmic reticulum stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

p53 antagonizes the unfolded protein response and inhibits ground glass hepatocyte development during endoplasmic reticulum stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Aneuploidy causes proteotoxic stress in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Proteostasis modulators prolong missense VHL protein activity and halt tumor progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

HDAC6-p97/VCP controlled polyubiquitin chain turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Endoplasmic reticulum stress, genome damage, and cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The impact of the endoplasmic reticulum protein-folding environment on cancer development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.03.007

10.1016/J.TRECAN.2016.03.007

7 January 2021

Identifiers

DOI

1 reference

12 September 2017

1 reference