(Q38132652)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Targeting the unfolded protein response in disease (English)

1 reference

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8 March 2020

3

1 reference

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8 March 2020

author name string

Claudio Hetz

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Eric Chevet

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

publication date

1 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

8 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

703-719

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23989796%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd3976

8 March 2020

exact match

0 references

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

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ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

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The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology

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Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments

21 January 2018

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On the mechanism of sensing unfolded protein in the endoplasmic reticulum

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Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response

21 January 2018

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Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β

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Modulating stress responses by the UPRosome: a matter of life and death

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

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Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.

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The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death

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ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease

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CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

21 January 2018

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The unfolded protein response in familial amyotrophic lateral sclerosis

21 January 2018

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

21 January 2018

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Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis

21 January 2018

1 reference

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

21 January 2018

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Activation of the unfolded protein response enhances motor recovery after spinal cord injury

21 January 2018

1 reference

Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury

21 January 2018

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Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

21 January 2018

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Endoplasmic reticulum stress in disorders of myelinating cells.

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

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Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis

21 January 2018

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The transcription factor XBP-1 is essential for the development and survival of dendritic cells

21 January 2018

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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling

21 January 2018

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Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.

21 January 2018

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21 January 2018

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The endoplasmic reticulum stress response in immunity and autoimmunity

21 January 2018

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Targeting endoplasmic reticulum stress in metabolic disease

21 January 2018

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

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Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

21 January 2018

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Regulation of hepatic lipogenesis by the transcription factor XBP1

21 January 2018

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Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction

21 January 2018

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The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

21 January 2018

1 reference

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

21 January 2018

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Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

21 January 2018

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ER stress controls iron metabolism through induction of hepcidin

21 January 2018

1 reference

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

21 January 2018

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The role of the unfolded protein response in tumour development: friend or foe?

21 January 2018

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Integrated endoplasmic reticulum stress responses in cancer

21 January 2018

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21 January 2018

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21 January 2018

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An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

21 January 2018

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Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth.

21 January 2018

1 reference

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

21 January 2018

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21 January 2018

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Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA.

21 January 2018

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p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose.

21 January 2018

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ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

21 January 2018

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ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.

21 January 2018

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Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis

21 January 2018

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ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

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GRP78 induction in cancer: therapeutic and prognostic implications.

21 January 2018

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The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

21 January 2018

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Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

21 January 2018

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Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

21 January 2018

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Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

21 January 2018

1 reference

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

21 January 2018

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Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

21 January 2018

1 reference

SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation.

21 January 2018

1 reference

Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. structure elucidation.

21 January 2018

1 reference

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

21 January 2018

1 reference

Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress.

21 January 2018

1 reference

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

21 January 2018

1 reference

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

21 January 2018

1 reference

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

21 January 2018

1 reference

Pharmacological brake-release of mRNA translation enhances cognitive memory

21 January 2018

1 reference

Translational control of long-lasting synaptic plasticity and memory

21 January 2018

1 reference

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

21 January 2018

1 reference

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase

21 January 2018

1 reference

Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma

21 January 2018

1 reference

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

21 January 2018

1 reference

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib

21 January 2018

1 reference

Failure of amino acid homeostasis causes cell death following proteasome inhibition.

21 January 2018

1 reference

Proteasome inhibitors: an expanding army attacking a unique target

21 January 2018

1 reference

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

21 January 2018

1 reference

GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy

21 January 2018

1 reference

Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.

21 January 2018

1 reference

Unfolded protein response in cancer: the physician's perspective

21 January 2018

1 reference

Effect on tumor cells of blocking survival response to glucose deprivation

21 January 2018

1 reference

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

21 January 2018

1 reference

Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells

21 January 2018

1 reference

Inhibition of HSP70: a challenging anti-cancer strategy

21 January 2018

1 reference

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

21 January 2018

1 reference

Hsp90 molecular chaperone inhibitors: are we there yet?

21 January 2018

1 reference

Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs

21 January 2018

1 reference

Protein disulfide isomerases in neurodegeneration: from disease mechanisms to biomedical applications

21 January 2018

1 reference

The protein disulfide isomerase family: key players in health and disease

21 January 2018

1 reference

Protein disulfide isomerase expression is related to the invasive properties of malignant glioma

21 January 2018

1 reference

Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.

21 January 2018

1 reference

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

21 January 2018

1 reference

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

21 January 2018

1 reference

Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

21 January 2018

1 reference

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

21 January 2018

1 reference

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

21 January 2018

1 reference

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

21 January 2018

1 reference

Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis

21 January 2018

1 reference

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans

21 January 2018

1 reference

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

21 January 2018

1 reference

Sodium 4-phenylbutyrate protects against cerebral ischemic injury.

21 January 2018

1 reference

Sodium 4-phenylbutyrate protects against spinal cord ischemia by inhibition of endoplasmic reticulum stress

21 January 2018

1 reference

Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion

21 January 2018

1 reference

Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis

21 January 2018

1 reference

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

21 January 2018

1 reference

InterfERing with endoplasmic reticulum stress

21 January 2018

1 reference

A molecular chaperone inducer protects neurons from ER stress

21 January 2018

1 reference

Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil

21 January 2018

1 reference

Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice

21 January 2018

1 reference

Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice

21 January 2018

1 reference

The protective effect of a newly developed molecular chaperone-inducer against mouse ischemic acute kidney injury

21 January 2018

1 reference

The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers

21 January 2018

1 reference

ER stress inhibits neuronal death by promoting autophagy

21 January 2018

1 reference

An update on gene therapy in Parkinson's disease

21 January 2018

1 reference

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

21 January 2018

1 reference

Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.

21 January 2018

1 reference

AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease

21 January 2018

1 reference

Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.

21 January 2018

1 reference

Protective effect against Parkinson's disease-related insults through the activation of XBP1

21 January 2018

1 reference

The role of PDI as a survival factor in cardiomyocyte ischemia

21 January 2018

1 reference

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

21 January 2018

1 reference

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

21 January 2018

1 reference

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory

21 January 2018

1 reference

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

21 January 2018

1 reference

The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling

21 January 2018

1 reference

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

Activating transcription factor 4.

21 January 2018

1 reference

Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.

21 January 2018

1 reference

Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress

21 January 2018

1 reference

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

21 January 2018

1 reference

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

21 January 2018

1 reference

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

31 March 2020

1 reference

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

31 March 2020

1 reference

Eeyarestatin causes cervical cancer cell sensitization to bortezomib treatment by augmenting ER stress and CHOP expression

31 March 2020

1 reference

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships

31 March 2020

1 reference

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

31 March 2020

1 reference

Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23989796

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Advances in the understanding of mechanisms and therapeutic use of bortezomib

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23989796