(Q39502722)

12 September 2017

title

Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase (English)

1 reference

12 September 2017

0 references

0 references

Sergio Hernán Szajnman

0 references

author name string

Sergio H Szajnman

1

1 reference

12 September 2017

Andrea Montalvetti

2

1 reference

12 September 2017

Youhong Wang

3

1 reference

12 September 2017

Roberto Docampo

4

1 reference

12 September 2017

Juan B Rodriguez

5

1 reference

12 September 2017

language of work or name

English

0 references

publication date

1 October 2003

1 reference

Bioorganic & Medicinal Chemistry Letters

12 September 2017

published in

1 reference

12 September 2017

volume

13

1 reference

12 September 2017

issue

19

1 reference

12 September 2017

page(s)

3231-3235

1 reference

Biology of Trypanosoma cruzi

12 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Sterol biosynthesis inhibitors: potential chemotherapeutics against Chagas disease

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Present status of chemotheraphy and chemoprophylaxis of human trypanosomiasis in the Western Hemisphere

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Specific molecular targets to control tropical diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Recent developments in the chemotherapy of Chagas disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Glycoinositolphospholipids, free and as anchors of proteins, in Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Mechanisms of action of bisphosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Therapeutic approaches to bone diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Bisphosphonate mechanism of action

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Protein prenyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Ras farnesyltransferase: a new therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Activity of bisphosphonates against Trypanosoma brucei rhodesiense

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

The cell biology of parasitism in Trypanosoma brucei: insights and drug targets from genomic approaches?

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

Regulation of product chain length by isoprenyl diphosphate synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900663-2

7 January 2021

10.1016/S0960-894X(03)00663-2

Identifiers

DOI

1 reference

12 September 2017

1 reference